富马酸喹硫平联合丙戊酸钠治疗双相障碍躁狂的临床效果及对心理状态的影响

Clinical Effect of Quetiapine Fumarate Combined with Sodium Valproate in the Treatment of Bipolar Disorder Mania and Its Influence on Psychological State

目的:探讨富马酸喹硫平联合丙戊酸钠治疗双相障碍躁狂的临床效果及对心理状态的影响。方法:选取2021年1月—2023年12月遵义市播州区舒心精神病医院收治的双相障碍躁狂患者80例为研究对象,随机分为对照组和观察组,各40例。对照组采用丙戊酸钠治疗,观察组在对照组基础上采用富马酸喹硫平治疗。比较两组治疗总有效率、贝克-拉范森躁狂量表(BRMS)评分、阳性和阴性症状量表(PANSS)评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.025)。治疗前,两组PANSS、BRMS评分比较,差异无统计学意义(P>0.05);治疗后,两组PANSS、BRMS评分低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组SAS、SDS评分比较,差异无统计学意义(P>0.05);治疗后,两组SAS、SDS评分低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丙戊酸钠联合富马酸喹硫平治疗双相障碍躁狂可提高治疗总有效率,改善临床症状、负面情绪,具有一定安全性。

Objective:To explore the clinical effect of quetiapine fumarate combined with sodium valproate in the treatment of bipolar disorder mania and its influence on psychological state.Methods:Eighty patients with bipolar disorder and mania admitted to Zunyi Bozhou District Shuxin Psychiatric Hospital from January 2021 to December 2023 were selected as the study objects,and randomly divided into control group and observation group,with forty patients in each group.The control group was treated with sodium valproate,and the observation group was treated with quetiapine fumarate based on the control group.The total effective rate,Baker-Lafansen Mania Scale(BRMS)score,Positive and Negative Symptom Scale(PANSS)score,Self-rating Anxiety Scale(SAS)score,Self-rating Depression Scale(SDS)score and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.025).Before treatment,there was no significant difference in PANSS and BRMS scores between the two groups(P>0.05);after treatment,PANSS and BRMS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in SAS and SDS scores between the two groups(P>0.05);after treatment,SAS and SDS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Sodium valproate combined with quetiapine fumarate in the treatment of bipolar disorder mania can improve the total effective rate,improve clinical symptoms and negative emotions,and have a certain safety.