硝苯地平联合硫酸镁治疗重度子痫前期的效果及对妊娠结局的影响

Effect of Nifedipine Combined with Magnesium Sulfate on Severe Preeclampsia and Its Influence on Pregnancy Outcome

目的:观察硝苯地平联合硫酸镁治疗重度子痫前期的效果及对妊娠结局的影响。方法:选取2020年1月—2023年12月连云港市第二人民医院收治的重度子痫前期患者60例为研究对象,随机分为对照组和观察组,各30例。对照组采用硫酸镁治疗,观察组在对照组基础上采用硝苯地平治疗。比较两组治疗总有效率、血压、24 h尿蛋白定量、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]及不良妊娠结局发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.001)。治疗前,两组舒张压、收缩压及24 h尿蛋白定量比较,差异无统计学意义(P>0.05);治疗后,两组舒张压、收缩压及24 h尿蛋白定量低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组Scr、BUN水平比较,差异无统计学意义(P>0.05);治疗后,两组Scr、BUN水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.001)。结论:硝苯地平联合硫酸镁治疗重度子痫前期的效果较好,可有效控制血压及24 h尿蛋白定量水平,改善肾功能,降低不良妊娠结局发生率。

Objective:To observe the effect of nifedipine combined with magnesium sulfate on severe preeclampsia and its influence on pregnancy outcome.Methods:Sixty patients with severe preeclampsia admitted to Lianyungang Second People's Hospital from January 2020 to December 2023 were selected as the study objects,and were randomly divided into control group and observation group,with thirty patients in each group.The control group was treated with magnesium sulfate,and the observation group was treated with nifedipine based on the control group.The total effective rate,blood pressure,24 h urinary protein quantity,renal function index[serum creatinine(Scr),blood urea nitrogen(BUN)]and incidence of adverse pregnancy outcome were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in diastolic blood pressure,systolic blood pressure and 24 h urinary protein quantity between the two groups(P>0.05);after treatment,the diastolic blood pressure,systolic blood pressure and 24 h urinary protein quantity of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in Scr and BUN levels between the two groups(P>0.05);after treatment,the Scr and BUN levels in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.001).Conclusion:Nifedipine combined with magnesium sulfate has a good effect in the treatment of severe preeclampsia,which can effectively control blood pressure and 24 h urinary protein quantitative level,improve kidney function and reduce the incidence of adverse pregnancy outcomes.