普罗布考联合瑞舒伐他汀治疗T2DM并脑梗死的效果及对血清内脂素及Hcy的影响研究

The effect of probucol combined with rosuvastatin in the treatment of type 2 diabetes mellitus with cerebral infarction and its effect on serum visfatin and homocysteine

目的:探讨普罗布考对2型糖尿病(Type 2 diabetes mellitus,T2DM)并脑梗死患者血清内脂素及同型半胱氨酸(Homocysteine,Hcy)的影响。方法:选取2021年1月至2022年12月于我院治疗的82例T2DM并脑梗死患者作为研究对象。按随机数字表法将患者分为对照组和研究组,各41例。对照组采用瑞舒伐他汀治疗;观察组在对照组的基础上联合普罗布考治疗。分析比较两组的临床疗效、血清内脂素、Hcy、颈动脉内膜斑块面积、颈动脉内膜中膜厚度(Carotid intima-media thickness,CAIMT),及不良反应。结果:观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组内脂素和Hcy水平、斑块面积和CAIMT均明显低于治疗前,且观察组明显低于对照组(P<0.05)。两组的不良反应发生率无明显差异(P>0.05)。结论:T2DM并脑梗死患者采用普罗布考联合瑞舒伐他汀治疗能够控制患者病情,缩小颈动脉斑块面积、CAIMT,降低血清内脂素及Hcy水平,改善患者神经功能,且并未增加明显不良反应。

Objective:To investigate the effect of probucol on serum visfatin and homocysteine(Hcy)in patients with type 2 diabetes mellitus(T2DM)and cerebral infarction.Methods:A total of 82 patients with T2DM and cerebral infarction treated in our hospital from January 2021 to December 2022 were selected as the research objects.The patients were divided into control group and study group according to the random number table method,with 41 cases in each group.The control group was treated with rosuvastatin;the observation group was treated with probucol on the basis of the control group.The clinical efficacy,serum visfatin,Hcy,carotid intima-media thickness(CAIMT),carotid intima-media thickness(CAIMT)and adverse reactions of the two groups were analyzed and compared.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of visfatin and Hcy,plaque area and CAIMT in the two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Treatment with probucol combined with rosuvastatin in patients with T2DM complicated with cerebral infarction can control the condition of patients,reduce the area of carotid plaque and CAIMT,reduce serum visfatin and Hcy levels,improve neurological function of patients,and does not increase obvious adverse reactions.