性激素水平在多囊卵巢综合征不孕患者中的临床意义分析

Analysis of clinical significance of sex hormone levels in infertility patients with polycystic ovary syndrome

目的:性激素指标在多囊卵巢综合征(Polycystic ovary syndrome,PCOS)不孕患者中的临床意义。方法:选取2020年1月至2023年6月期间本院检验科诊断的60例PCOS不孕症患者作为研究对象。全部患者接受常规PCOS不孕治疗。随访6 m,记录患者治疗后自然受孕情况,并将患者分为未受孕患者和自然受孕患者。分析不同受孕情况患者的基线资料及性激素水平[孕激素(Progestin,P)、卵泡刺激素(Follicle-stimulating hormone,FSH)、泌乳素(Prolactin,PRL)、雌二醇(Estradiol,E_(2))、睾酮(Tsetosterone,T)及黄体生成素(Luteinizing hormone,LH)]水平,分析性激素指标与PCOS不孕患者自然受孕结局的关系。结果:PCOS不孕患者经治疗后自然受孕失败30例,占50.00%。未受孕患者治疗前的P、PRL、T、LH、FSH水平均显著高于自然受孕患者,E_(2)水平明显低于自然受孕患者(P<0.05)。经回归分析结果显示,PCOS不孕患者P、PRL、T、LH、FSH可能是自然受孕失败的风险因子(OR>1,P<0.05),E_(2)是其保护因子(OR<1,P<0.05)。结论:PCOS不孕患者若表现为性激素水平明显异常,可能会导致治疗后自然受孕失败。

Objective:To investigate the clinical significance of sex hormone indexes in infertility patients with polycystic ovary syndrome(PCOS).Methods:A total of 60 patients with PCOS infertility diagnosed by the clinical laboratory of our hospital from January 2020 to June 2023 were selected as the research objects.All patients received conventional PCOS infertility treatment.The patients were followed up for 6 months,and the natural conception of the patients after treatment was recorded,and the patients were divided into non-pregnant patients and natural conception patients.The baseline data and sex hormone levels[Progestin(P),Follicle-stimulating hormone(FSH),Prolactin(PRL),Estradiol(E2),Tsetosterone(T)and Luteinizing hormone(LH)]of patients with different pregnancy conditions were analyzed,and the relationship between sex hormone indexes and natural pregnancy outcome of PCOS infertile patients was analyzed.Results:30 cases(50.00%)of 60 PCOS infertility patients failed to conceive naturally after treatment.The levels of P,PRL,T,LH and FSH in non-pregnant patients before treatment were significantly higher than those in natural pregnant patients,and the levels of E2 were significantly lower than those in natural pregnant patients(P<0.05).The regression analysis results showed that P,PRL,T,LH,and FSH may be risk factors for natural conception failure in PCOS infertility patients(OR>1,P<0.05),and E2 was its protective factor(OR<1,P<0.05).Conclusion:Abnormal sex hormone levels in PCOS infertile patients may lead to failure of natural conception after treatment.