腹腔镜胆囊切除术与开腹手术对胆囊结石患者的影响

Effect of laparoscopic cholecystectomy and open surgery on patients with gallstones

目的:探究腹腔镜胆囊切除术与开腹手术对胆囊结石患者的影响。方法:回顾性收集自2019年5月至2023年10月本院收治的104例胆囊结石患者的临床资料,根据手术方法将患者分为对照组(开腹手术,n=51)与观察组(腹腔镜胆囊切除术,n=53)。分析对比两组的治疗疗效;术后3 d采用酶联免疫法检测P物质、5-羟色胺以及去甲肾上腺素(Norepinephrine,NE)水平;术后1 w内评估患者术后恢复情况并于出院前判断患者术后并发症发生情况。结果:观察组的治疗有效率显著高于对照组(P<0.05)。术后3 d,两组的P物质、5-羟色胺、NE水平均上升,且观察组的P物质、5-羟色胺、NE水平均显著低于对照组(P<0.05)。观察组的肛门排气时间、下床活动时间以及住院时间均显著短于对照组(P<0.05)。观察组(5.66%)术后并发症发生率显著低于对照组(19.60%)(P<0.05)。结论:与传统开腹手术相比较,腹腔镜胆囊切除术对胆囊结石患者的临床疗效更好,能减轻术后的疼痛感,促进患者术后恢复,降低并发症发生率。

Objective:To explore the effects of laparoscopic cholecystectomy and open surgery on patients with gallstones.Methods:The clinical data of 104 patients with cholecystolithiasis admitted to our hospital from May 2019 to October 2023 were retrospectively collected.Patients were divided into the control group(open surgery,n=51)and the observation group(laparoscopic cholecystectomy,n=53)according to the differences in surgical methods.The therapeutic effects of the two groups were analyzed and compared.Substance P,serotonin,and Norepinephrine(NE)were detected by enzyme-linked immunoassay(ELISA)three days after operation.The postoperative recovery of patients was assessed within one week after surgery and the occurrence of postoperative complications was determined before discharge.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After 3 days of operation,the levels of substance P,serotonin,and NE in both groups were increased,and all of them in the observation group were significantly lower than those in the control group(P<0.05).The time of anal exhaust,the time of getting out of bed and the time of hospitalization in the observation group were significantly shorter than those in the control group(P<0.05).The incidence of postoperative complications in the observation group(5.66%)was markedly lower than that in the control group(19.60%)(P<0.05).Conclusion:Compared with traditional open surgery,laparoscopic cholecystectomy has a better clinical effect on patients with gallstones,which can alleviate postoperative pain,promote postoperative recovery,and reduce the incidence of complications.