樟脑酚与氢氧化钙对慢性牙髓炎患者的有效性与安全性研究

Study on the efficacy and safety of camphorphenol and calcium hydroxide in patients with chronic pulpitis

目的:探讨慢性牙髓炎患者治疗中应用樟脑酚与氢氧化钙的疗效。方法:选取2020年1月至2022年1月本院收治的100例慢性牙髓炎患者作为研究对象。采用随机数字表法将患者分为对照组与观察组,各50例。对照组应用樟脑酚填充;观察组应用氢氧化钙填充。于治疗1 m后评估对比两组的临床总有效率、治疗前与治疗7 d的视觉模拟疼痛(visual analogue scale,VAS)评分及血清炎症因子水平、治疗前与治疗1 m的牙齿功能指标(咀嚼效能、咬合力、牙龈指数)、不良反应发生率。结果:观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的VAS评分、患牙活动度评分均显著下降,且观察组的降低幅度显著大于对照组(P<0.05)。治疗后,两组的牙齿功能即咀嚼效能、咬合力、牙龈指数均显著改善,且观察组的改善幅度显著高于对照组(P<0.05)。治疗后,两组的肿瘤坏死因子-α、白介素-8水平均呈下降趋势,且观察组均显著低于对照组(P<0.05)。两组的不良反应发生率无显著差异(P>0.05)。结论:将氢氧化钙应用于慢性牙髓炎的治疗中,能提高临床疗效,减轻疼痛和炎症,改善牙齿活动度和牙齿功能。

Objective:To explore the efficacy of camphorphenol and calcium hydroxide in the treatment of chronic pulpitis.Methods:The 100 patients with chronic pulpitis admitted to our hospital from January 2020 to January 2022 were selected as the research object.The patients were randomly divided into control group and observation group,with 50 cases in each group.The control group was filled with camphor phenol;The observation group was filled with calcium hydroxide.After one month of treatment,the clinical total effective rate,visual analogue scale(VAS)score and serum inflammatory factors before and after treatment for 7 days,dental function indexes(masticatory efficiency,bite force,gingival index)before and after treatment for 1 month,and the incidence of adverse reactions were evaluated and compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the VAS score,and the dental mobility score of the two groups decreased significantly,and the decrease of the observation group was significantly greater than that of the control group(P<0.05).After treatment,the dental functions of the two groups,namely,masticatory efficiency,bite force and gingival index,were significantly improved,and the improvement range of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of tumor necrosis factor-αand interleukin-8 in both groups showed a downward trend,and the observation group was significantly lower than the control group(P<0.05).Conclusion:The application of calcium hydroxide in the treatment of chronic pulpitis can improve the clinic.