摘要
目的:探讨血清白细胞介素33(Interleukin-33,IL-33)与中性粒细胞/淋巴细胞比值(Neutrophil-to-lymphocyte ratio,NLR)水平变化对重型肝病患者病情进展的预测价值。方法:选取本院2019年6月至2023年9月收治的72例肝衰竭患者为重症组,72例慢性乙肝患者为肝炎组,另收集144例同期健康体检者为对照组。对比三组患者及不同预后患者血清IL-33、NLR及谷丙转氨酶(Alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(Aspartate transaminase,AST)、总胆红素(Total bilirubin,TBIL)水平,分析其相关性及对预后的预测价值。结果:重症组血清IL-33、NLR及AST、ALT、TBIL水平显著高于肝炎组及对照组(P<0.05)。血清IL-33、NLR与AST、ALT、TBIL呈正相关(P<0.05)。重症组预后不良患者血清IL-33、NLR均高于预后良好患者(P<0.05)。血清IL-33、NLR联合检测对患者预后不良的预测价值较高。结论:血清IL-33、NLR水平与重型肝病患者病情相关,临床检测其水平对评估病情进展具有重要价值。
Objective:To investigate the predictive value of changes in serum interleukin-33(IL-33)and neutrophil-to-lymphocyte ratio(NLR)levels for the progression of severe liver disease in patients.Methods:Seventy-two patients with liver failure admitted to our hospital from June 2019 to September 2023 were selected as the critical group,72 patients with chronic hepatitis B were selected as the hepatitis group,and another 144 patients with health checkup in the same period were collected as the control group.The levels of serum IL-33,NLR,alanine aminotransferase(ALT),aspartate transaminase(AST),and total bilirubin(TBIL)were compared among the three groups of patients and patients with different prognoses,and their correlation and prognostic prediction value were analyzed.Results:The levels of serum IL-33,NLR,AST,ALT,and TBIL in the severe group were significantly higher than those in the hepatitis group and the control group(P<0.05).Serum IL-33 and NLR were positively correlated with AST,ALT,and TBIL(P<0.05).The serum IL-33 and NLR levels in patients with poor prognosis were higher than those in patients with good prognosis(P<0.05).The combined detection of serum IL-33 and NLR had a high predictive value for poor prognosis in patients.Conclusion:The levels of serum IL-33 and NLR are correlated with the severity of severe liver disease,and clinical detection of their levels is of great value for evaluating disease progression.
作者
何丹丹
He Dan-dan(Department of Infection,Guangshan People's Hospital,Xinyang 465450,Henan,China)
