CGF在上颌前牙区单牙缺失伴唇侧水平向骨缺损患者骨再生术治疗中的应用价值及其对牙周状况的影响

Application value of GF in the treatment of single tooth loss in anterior maxillary region with labial horizontal bone defect and its influence on periodontal status

目的:探究浓缩生长因子(Concentrated growth factor,CGF)在上颌前牙区单牙缺失伴唇侧水平向骨缺损患者骨再生术治疗中的应用价值及其对牙周状况的影响。方法:选取太康县人民医院口腔科2019年3月至2021年3月期间111例上颌前牙区单牙缺失伴唇侧水平向骨缺损患者作为本次的研究对象,随机分为对照组(n=55)和观察组(n=56)。对照组予以骨粉+胶原膜行常规引导骨再生术,观察组在对照组的基础上联合CGF治疗。观察两组患者软组织伤口一期愈合率、术后3及6 m骨再生情况、术前和术后6 m的牙周情况。结果:观察组的一期愈合率(94.64%)显著高于对照组(81.82%)(P<0.05);术后6 m,观察组的骨密度、新生骨厚度、骨宽度以及骨宽度增加量均明显高于对照组(P<0.05),术牙位局部探诊深度、垂直附着丧失、水平附着丧失均明显低于对照组(P<0.05)。结论:CGF可明显加快上颌前牙区单牙缺失伴唇侧水平向骨缺损患者的软组织伤口愈合速度,改善患者的骨再生情况,增加患者骨密度、骨厚度、骨宽度,改善患者的牙周情况。

Objective:to explore the value of concentrated growth factor in the treatment of bone regeneration in patients with single tooth loss and labial horizontal bone defect in maxillary anterior teeth and its effect on periodontal status.Methods:111 patients with single tooth loss in maxillary anterior teeth with labial horizontal bone defect in the Department of Stomatology of Taikang County people's Hospital from March 2019 to March 2021 were randomly divided into control group(nasty 55)and observation group(nasty 56).The control group was given bone powder plus collagen membrane for routine guided bone regeneration,and the observation group was treated with CGF on the basis of the control group.The primary healing rate of soft tissue wound,bone regeneration 3 and 6 months after operation,and periodontal condition before and 6 months after operation were observed in the two groups.Results:the primary healing rate of the observation group(94.64%)was significantly higher than that of the control group(81.82%)(P<0.05).Six months after operation,the bone mineral density,new bone thickness,bone width and the increase of bone width in the observation group were significantly higher than those in the control group(P<0.05).The local probing depth,vertical attachment loss and horizontal attachment loss in the surgical tooth position were significantly lower than those in the control group(P<0.05).Conclusion:CGF can significantly accelerate the healing rate of soft tissue wound in patients with single tooth loss in maxillary anterior tooth with labial horizontal bone defect,improve bone regeneration,increase bone mineral density,bone thickness,bone width and improve periodontal condition.