四阴性乳腺癌的研究现状

Current status of research on quadruple-negative breast cancer

三阴性乳腺癌(TNBC)通常在年轻女性群体中被发现,是最具有侵袭性的一种乳腺癌亚型。随着对TNBC临床研究的逐渐深入,雄激素受体(AR)显示出其作为治疗靶点的重要作用。而目前对于AR阴性的TNBC,即四阴性乳腺癌(QNBC)的研究有限,缺乏明确的治疗标准。将QNBC作为乳腺癌的独立亚型对于提高精准治疗的疗效具有十分重要的意义。本文综合阐述了近年来对于QNBC的研究进展,简要介绍了QNBC的流行病学,总结了AR的检测方法,梳理了其潜在的治疗靶点,以期为QNBC患者提供更为有效的治疗方案。

Triple-negative breast cancer(TNBC)is usually found in the younger female population and is one of the most aggressive subtypes of breast cancer.With the gradual deepening of clinical research on TNBC,androgen receptor(AR)has shown its important role as a therapeutic target.At present,the researches on AR negative-TNBC,namely quadruple-negative breast cancer(QNBC)are limited,and there is a lack of clear treatment standards.It is of great significance to regard QNBC as an independent subtype of breast cancer to improve the efficacy of precision therapy.This article provides a comprehensive overview of the recent research progress on QNBC.It briefly introduces the epidemiology of QNBC and summarizes the detection methods of the AR.Additionally,it examines potential therapeutic targets associated with QNBC,in order to provide more effective treatment for patients with QNBC.