基于玄府理论分析虫类药物在甲状腺相关眼病中的应用

Analysis of the Application of Insect-derived Medicines in Thyroid-associated Oph-thalmopathy Based on the Xuanfu Theory

甲状腺相关眼病(TAO)发病机制复杂,病程长,预后不良,属久病顽疾。近年来,玄府理论作为一种中医学基本理论被广泛应用于TAO的临床诊疗中。玄府郁闭是TAO的基本病机,初见气郁玄府,久则痰湿、瘀血阻塞玄府。虫类药均为血肉有情之品,根据其“飞升走窜,无微不至”的特性,从清肝泻火、行气开玄府和化瘀散结、搜剔开玄府2个方面治疗TAO,为中医临床治疗TAO提供新思路。

The pathogenesis of thyroid-associated ophthalmopathy(TAO)is complex,characterized by a long disease course and poor prognosis,thus making it a chronic and refractory condition.In recent years,Xuanfu theory,a fundamental theory in Traditional Chinese Medicine(TCM),has been widely applied in the clinical diagnosis and treatment of TAO.The blockage of Xuanfu is the basic pathogenesis of TAO,initially manifesting as Qi stagnation in Xuanfu and eventually leading to the obstruction of Xuanfu by phlegm,dampness,and blood stasis over time.Medicinal substances derived from insects,known for their"ascending,dispersing,and thorough"properties,are utilized in the treatment of TAO.These treatments involve two main approaches:Clearing liver and purging fire to regulate Qi and open Xuanfu,and resolving stasis and dispersing nodules to dredge and unblock Xuanfu.This provides new insights for the clinical treatment of TAO using TCM.