中药微针:创新的中药给药方式

Chinese medicine microneedles:innovative traditional Chinese medicine delivery methods

中药微针是一种将中药活性成分直接递送至表皮层或真皮层的新型给药方式,可大大减轻患者的痛感,提高透皮给药效率,且能绕过传统中药口服的肝脏首过效应。本文阐述了中药微针的概念、研究进展、存在的问题以及其发展前景。进一步通过介绍中药微针的制备方法和设计因素,总结出影响中药微针机械强度、载药量和透皮深度的主要因素,为中药微针的优化设计提供了参考。

Traditional Chinese medicine-loaded microneedles are a kind of novel drug delivery method to deliver the active ingredients of traditional Chinese medicine directly to the epidermis or dermis,which can greatly reduce patients′pain and improve the efficiency of transdermal drug delivery,and also can bypass the hepatic first-pass effect of orally taken traditional Chinese medicine.This paper describes the concept of traditional Chinese medicine-loaded microneedles,research progress,existing problems,and their development prospects.Here we also have summarized the main factors affecting the mechanical strength,drug loading capacity,and transdermal depth of traditional Chinese medicine-loaded microneedles by introducing the preparation methods and design factors of traditional Chinese medicine-loaded microneedles,which provides a reference for the optimal design of traditional Chinese medicine-loaded microneedles.