血镁在慢性肾脏病及其矿物质与骨异常中作用的研究进展

Role of blood magnesium in mineral and bone disorders related to chronic kidney disease

慢性肾脏病矿物质和骨异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)是慢性肾脏病(chronic kidney disease,CKD)患者的常见并发症,是一种涉及不同矿物质和骨代谢异常的全身性疾病,也包括血管钙化的发生,对患者的生存质量和长期预后产生重要影响。尽管多年来对CKD-MBD发病机制的认识已不断完善,但血镁水平对其演变的影响和重要性直到近年才得到重视。本文综述了血镁的生理功能、血镁与CKD及CKD-MBD的关系及相互作用机制,调控血镁水平有可能成为治疗CKD-MBD的新靶点。

Chronic kidney disease(CKD)mineral and bone disorder(CKD-MBD)is a common complication in CKD patients.CKD-MBD as a systemic disease is involved in a variety of mineral and bone metabolism abnormalities such as changes in bone density and bone strength and vascular calcification,contributing to an important impact on quality of life and long-term prognosis of the patients.Although our understanding of the pathogenesis of CKD-MBD has been improved for many years,blood magnesium on the evolution of CKD-MBD has not been appreciated until recent years.Studies have found that blood magnesium and CKDMBD may be closely related,but the available data remain to be equivocal.Further studies are required to confirm these findings.In this paper,the physiological function of magnesium,the relationship between magnesium and CKD and CKD-MBD,and their interactions are reviewed.We suggest that regulation of blood magnesium level may be a new target for the treatment of CKD-MBD.