老年高血压患者并发肌少症的相关因素分析

Analysis of Factors Associated with Complications of Sarcopenia in Elderly Hypertensive Patients

目的分析老年高血压患者并发肌少症的相关危险因素。方法选取2022年5—10月就诊于内蒙古自治区人民医院的≥60岁的确诊为高血压的152例患者进行相关因素分析,根据肌少症诊断标准将所有入组患者分为肌少症组和非肌少症组进行研究。结果本研究中≥60岁的高血压患者并发肌少症的总患病率为41.45%(63/152);其中,男性患病率为47.69%(31/65),女性患病率为36.78%(32/87)。两组患者性别、民族、肌酐(Cr)、血糖(GLU)、胆固醇(TC)、高密度脂蛋白(HDL-C)、甘油三酯(TG)、门冬氨酸氨基转移酶(AST)、丙氨酸转移酶(ALT)比较,差异无统计学意义(P>0.05);两组患者年龄、身体质量指数(BMI)、胰岛素样生长因子-1(IGF-1)、25-羟维生素D_(3)[25(OH)D_(3)]、白介素-6(IL-6)、血尿素氮(BUN)、肌酸激酶(CK)比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,BMI、IGF-1、IL-6、CK是高血压患者并发肌少症的独立危险因素(P<0.05)。结论老年高血压并发肌少症患病率较高,低BMI、低IGF-1、高IL-6及低CK水平是高血压患者并发肌少症的独立危险因素。

Objective To analyze the complication of sarcopenia in elderly hypertensive patients and related risk factors.Methods A total of 152 patients≥60 years old diagnosed with hypertension attending the Inner Mongolia Autonomous Region People's Hospital from 2022 May October were analyzed for relevant factors,and all enrolled patients were divided into oligohydramnios and non-oligohydramnios groups according to the diagnostic criteria of oligohydramnios for the study.Results The overall prevalence of myasthenia gravis in hypertensive patients≥60 years of age in this study was 41.45%(63/152),with a prevalence of 47.69%(31/65)in males and 36.78%(32/87)in females.There was no statistically significant difference between the 2 groups in terms of gender,ethnicity,Cr,GLU,GHO,HDL-C,TG,AST,and ALT(P>0.05);the differences in the 2 groups were not statistically significant(P>0.05);when comparing the age,BMI,IGF-1,25(OH)D_(3),IL-6,BUN,and CK of the hypertensive patients in the 2 groups,the difference was statistically significant(P<0.05).The results of multifactorial logistic regression analysis showed that BMI,IGF-1,IL-6,and CK were independent risk factors for the complication of sarcopenia in hypertensive patients(P<0.05).Conclusion The prevalence of complicated sarcopenia was higher in elderly hypertensive patients,and low BMI,low IGF-1,high IL-6 and low CK levels were independent risk factors for complicated sarcopenia in hypertensive patients.