基于调控血管新生的角度探讨中医药防治缺血性脑卒中

Exploration of the Prevention and Treatment of Ischemic Stroke by Traditional Chinese Medicine from the Perspective of Regulating Angiogenesis

缺血性脑卒中作为严重危害生命健康的主要疾病之一,其发病率、复发率、致死致残率较高,通过文献总结发现多种血管生成相关分子标记物通过调节内皮细胞、血管壁重塑、抑制炎症反应、保护神经功能、修复血脑屏障已成为缺血性脑卒中的治疗靶点,血管新生与中医脉络学说息息相关,活血化瘀通络、清热滋阴平肝类中药活性成分及中药复方可多靶点、多通路促进血管新生,从而改善脑缺血及神经功能,该文基于血管新生综述中医药及有效成分在缺血性脑卒中中的研究进展,从血管新生角度探讨中医药防治缺血性脑卒中的可能作用机制。

As one of the major diseases that seriously endanger life safety,ischemic stroke has a high incidence,recurrence rate,mortality and disability rate.Through literature review,it is found that a variety of molecular markers related to angiogenesis have become the therapeutic targets of ischemic stroke by regulating endothelial cells and vascular wall remodeling,inhibiting inflammatory response,protecting nerve function and repairing blood-brain barrier.Angiogenesis is closely related to the theory of collaterals of traditional Chinese medicine.The active components and traditional Chinese medicine compounds of promoting blood circulation,removing blood stasis and dredging collaterals,clearing heat,nourishing yin and calming liver can promote angiogenesis in multiple targets and pathways,so as to improve cerebral ischemia and nerve function.This article reviews the research progress of traditional Chinese medicine and its active ingredients in ischemic stroke based on angiogenesis,and discusses the possible mechanism of traditional Chinese medicine in preventing and treating ischemic stroke from the perspective of angiogenesis.