地奥司明联合艾瑞昔布对骨质疏松性四肢骨折患者炎症因子及骨代谢水平的影响分析

Analysis of the effects of dioxamine and ericoxib on inflammatory factors and bone metabolism in patients with osteoporotic limb fractures

目的分析探讨地奥司明联合艾瑞昔布对骨质疏松性四肢骨折患者炎症因子及骨代谢水平的影响。方法选取某院2021年6月~2023年7月收治的100例骨质疏松性四肢骨折患者,随机将患者分为观察组与对照组各50例。两组患者均行四肢骨折手术治疗,对照组患者术后口服艾瑞昔布片治疗,观察组术后口服地奥司明+艾瑞昔布治疗,两组均进行为期2周的持续治疗。比较两组疗效、不良反应发生率、治疗前后炎症因子及骨代谢水平。结果治疗后,观察组总有效率显著高于对照组(P<0.05),两组不良反应比较差异无统计学意义(P>0.05);观察组白细胞介素2(IL-2)、白细胞介素10(IL-10)、活性骨碱性磷酸酶(BALP)、骨钙素(OC)及Ⅰ型胶原C-末端肽交联(S-CTX)水平均高于对照组(P<0.05),降钙素原(PCT)及肿瘤坏死因子α(TNF-α)水平均低于对照组(P<0.05)。结论地奥司明联合艾瑞昔布治疗骨质疏松性四肢骨折患者疗效确切,可通过调节患者炎症因子指标,抑制炎性反应和调节骨代谢来促进骨折愈合和伤口恢复。

Objective To analyze and investigate the effects of dioxamine combined with ericoxib on inflammatory factors and bone metabolism in osteoporotic limb fractures.Methods The study included a total of 100 patients with osteoporotic limb fractures who were admitted to hospital between June 2021 and July 2023.These patients were randomly assigned into two groups:an observation group and a control group,each consisting of 50 cases.Both groups underwent surgical treatment for limb fracture.The control group was treated with oral ericoxib tablets after surgery,and the observation group was treated with oral diosamine combined with ericoxib,both groups underwent continuous treatment for 2 weeks.The efficacy,incidence of adverse reactions,inflammatory factors and bone metabolism were compared between two groups.Results After treatment,total effective rate of the observation group was significantly higher than that of the control group(P<0.05),and there was no significant difference in adverse reactions between the two group(s P>0.05).The levels of interleukin2(IL-2),interleukin10(IL-10),active bone alkaline phosphatase(BALP),osteocalcin(OC)and C-terminal peptide crosslinking(S-CTX)of type I collagen in the observation group were higher than those in the control group(P<0.05).The levels of procalcitonin(PCT)and tumor necrosis factorα(TNF-α)were lower than those in the control group(P<0.05).Conclusion Dioxamine combined with ericoxib is effective in the treatment of patients with osteoporotic limb fractures.It can promote fracture healing and wound recovery by regulating inflammatory factors,inhibiting inflammatory response and regulating bone metabolism.