利用HIS和CHPS系统探索头孢唑肟治疗新生儿感染的有效性及安全性

Exploring the efficacy and safety of cefazoxime in treating neonatal infections using HIS and CHPS systems

目的探索头孢唑肟治疗新生儿感染的有效性及安全性,为头孢唑肟在新生儿中的合理用药提供依据。方法采用回顾性研究,在HIS系统上收集新生儿科2021年1月~12月使用头孢唑肟进行抗感染治疗的患儿数据,根据用药情况分为观察组(联用青霉素类药物)与对照组(未联用青霉素类药物),并利用中国医院药物警戒系统(CHPS)检索不良反应,共纳入160例患儿,进行治疗有效性及安全性评价。结果观察组与对照组的72 h抗感染疗效及最终临床转归比较,差异无统计学意义(P>0.05),而两组的住院天数比较差异有统计学意义(P<0.05)。结论头孢唑肟对新生儿常见感染疾病有治疗作用,但经验性使用头孢唑肟联合青霉素类药物抗感染治疗疗效与单用头孢唑肟优势不大,反而延长了住院天数,临床医生应谨慎联合用药。

Objective To explore the efficacy and safety of cefazoxime in the treatment of neonatal infection,in order to provide evidence for rational use of cefazoxime in neonates.Methods A retrospective observational study was conducted to collect the data of children receiving antiinfective treatment with cefazolme in neonatology department from January 2021 to December 2021 on HIS system,and they were divided into the observation group(combined with penicillins)and the control group(not combined with penicillins)according to drug use.The Chinese hospital pharmacovigilance system(CHPS)was used to search for adverse reactions,a total of 160 children were included to evaluate the treatment efficacy and safety.Results There was no significant difference between the observation group and the control group in 72-hour anti-infective efficacy and final clinical outcome(P>0.05),but there was a statistical difference between the two groups in hospitalization days(P<0.05).Conclusion Cefazoxime is effective in the treatment of common infections in newborns,but the empirical use of cefazoxime combined with penicillin has little advantage over cefazoxime alone in anti-infection treatment,but extends the average length of hospital stay.Clinicians should be cautious with combined use of cefazoxime.