一例临床药师参与卵巢癌患者使用帕博利珠单抗致免疫相关性肺炎和心肌炎的病例分析

A case study of a clinical pharmacist's involvement in immune-associated pneumonia and myocarditis caused by pembrolizumab in a patient with ovarian cancer

目的分析1例帕博利珠单抗致免疫相关性肺炎和心肌炎的临床特点、发生机制及诊治方案。方法临床药师检索相关文献,总结帕博利珠单抗治疗卵巢癌癌诱发免疫相关性肺炎和心肌炎的临床特点、发生机制,并协助诊治。结果经积极治疗后,患者转归较好。结论临床药师参考免疫毒性管理指南对不良反应进行分级,给出治疗建议,转归较好,体现了临床药师的服务价值。

Objective To analyse the clinical characteristics,occurrence mechanism,diagnosis and treatment plan of one case of pablizumab induced immune-associated pneumonia and myocarditis.Methods Clinical pharmacists searched the relevant literature to summarize the clinical characteristics,occurrence mechanism of pablizumab induced immune-associated pneumonia and myocarditis,and assisted in diagnosis and treatment.Results After active treatment,the patient's regression was better.Conclusion The clinical pharmacists graded the adverse effects by referring to the guidelines for immunotoxicity management,and therapeutic recommendations were given,which resulted in a better regression,reflecting the value of the services provided by clinical pharmacists.