水凝胶材料在肾组织工程中的应用研究

Application of hydrogel materials in renal tissue engineering

急性肾损伤是全球关注的公共卫生问题,其治疗和管理策略不断进步。除了传统的肾脏替代疗法外,近年来的研究还集中在全器官工程以及用于体内再生的肾脏辅助设备和制剂的生物制造上。水凝胶材料因其良好的生物相容性、热稳定性和可调控的生化及力学性能,在肾组织工程中显示出巨大的潜力。该文综述了各类水凝胶材料在肾组织工程中用于促进肾脏再生方面的研究,讨论了天然水凝胶和合成水凝胶各自的特点与用途,旨在进一步推动其在临床中的应用。

Acute kidney injury is a worldwide public health issue,and its treatment and management strategies continue to advance.In addition to traditional kidney replacement therapy,research in recent years has been focused on whole organ engineering and biofabrication of kidney assistive devices and bioinjections for in-body regeneration.Hydrogel materials show great potential in renal tissue engineering because of their good biocompatibility,thermal stability and controllable biochemical and mechanical properties.This article reviews the application of various hydrogel materials in renal tissue engineering to promote kidney regeneration and discusses the characteristics and applications of natural hydrogels and synthetic hydrogels,which is expected to further promote their clinical applications.