Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
摘要
To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the cleavage of viral polyprotein and intercepting the deubiquitination and deISGylation functions to restore antiviral immunity1.
基金
National Natural Science Foundation of China(82151219,82130105)
the Strategic Priority Research Program of Chinese Academy of Sciences(SIMM010109,SIMM010111)
Shanghai Institute of Materia Medica of Chinese Academy of Sciences(SIMM0120231003)for the financial support.
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