甘草干姜汤古今组方用药规律分析

Analysis and comparison of prescription rules of Licorice and Dried Ginger Decoction in ancient and modern times

目的对甘草干姜汤在古代中医典籍和现代中医临床处方中的组方用药配伍规律进行分析并比较其异同。方法分别从《中医方剂大辞典》和河南中医药大学第一附属医院2017-2019年医生开具的住院处方中,筛选含有甘草-干姜、炙甘草-干姜、甘草-炮姜或炙甘草-炮姜药对的所有方剂,组方统一标准化后,运用SPSS v18.0和Cytoscape等软件,对提取的数据进行用药频次、剂量、配伍比例、疾病科属等统计和比较分析。结果分别从《中医方剂大辞典》和临床处方中筛选出2743首和24354首符合要求的组方,其中含炙甘草-干姜的方剂出现频次最多,分别占比59.8%和48.0%;且在筛选所得的组方中,以1∶1配比出现的频次最高。《中医方剂大辞典》中含有甘草-干姜、炙甘草-干姜所治疾病科属以脾胃病为主,甘草-炮姜和炙甘草-炮姜所治疾病科属以妇科病为主;现代中医临床处方中,甘草-干姜、甘草-炮姜和炙甘草-干姜所治疾病科属以脾胃肝胆科为主,炙甘草-炮姜所治疾病科属以产科为主。结论甘草干姜汤古今应用以炙甘草-干姜1∶1配比最为常用,所治疾病以脾胃病为主,为该药对的现代临床应用及科学研究的开展提供依据。

Objective To analyze and compare the similarities and differences in the pattern of grouping and medication dispensing of Licorice and Dried Ginger Decoction in ancient Chinese medicine dictionaries and modern Chinese medicine clinical prescriptions.Methods From the Dictionary of Traditional Chinese Medicine Formulas and the inpatient prescriptions issued bydoctors of First Affiliated Hospital of Henan University of Chinese Medicine from 2017 to 2019,respectively,all formulas containing licorice-dried ginger,prepared licorice-dried ginger,licorice-canned ginger,or prepared licorice-canned ginger pairs were screened,and the groupings were standardized uniformly,and software such as SPSS v18.0 and Cytoscape were applied.The extracted data were statistically and comparatively analyzed in terms of frequency of medication,dosage,proportion of compounding,and disease family.Results 2743 and 24354 formulas were screened from the Dictionary of Traditional Chinese Medicine Formulas and clinical prescriptions,respectively.Among them,formulas containing prepared licorice and dried ginger,which accounted for 59.8%and 48.0%of the total number of formulas respectively,appeared most frequently,and among the formulas obtained from the screening,the frequency of the 1:1 ratio was the highest.In the Dictionary of Chinese Medicine Formulas,the disease families treated by licorice-dried ginger,prepared licorice-dried ginger were mainly spleen and stomach diseases,and the disease families treated by licorice-canned ginger and prepared licorice-canned ginger were mainly gynecological diseases;in the clinical prescriptions of modern Chinese medicine,the disease families treated by licorice-dried ginger,licoricecanned ginger and prepared licorice-dried ginger were mainly spleen,stomach,liver,and gallbladder diseases,and the disease families treated by prepared licorice-canned ginger were mainly obstetrics and gynaecology diseases.Conclusion The ancient and modern applications of Licorice and Dried Ginger Decoction are most commonly used in the ratio of 1:1 of prepared licorice-dried ginger,and the diseases treated are mainly in the spleen and stomach,and this study can provide a basis for the modern clinical application of this medicinal pair and the development of scientific research.