中药单体靶向缺血性脑卒中相关通路的药理作用机制研究进展

Research progress on pharmacological mechanism of monomer components from traditional Chinese medicine targeting pathways related to cerebral ischemic stroke

缺血性脑卒中(CIS)因其高致残率、高病死率和高复发率,严重影响患者生活质量。研究发现中药单体可通过多种信号通路防治CIS,如姜黄素、青蒿琥酯、黄芩苷、丹酚酸D、柴胡皂苷A、小檗碱、黄藤素、异钩藤碱、雷公藤甲素、黄芪甲苷、红景天苷、人参皂苷Rg1、蒲公英甾醇、芍药苷等中药单体可以通过调控核因子κB(NF-κB)、高迁移率族蛋白B1(HMGB1)、单磷酸腺苷活化蛋白激酶(AMPK)、哺乳动物雷帕霉素靶蛋白(mTOR)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、核转录因子红系2相关因子2(Nrf2)等信号通路防治CIS。对中药单体对以上6条信号通路影响的相关机制进行综述,以期为CIS防治的深入研究提供新思路与新方向,同时为临床上运用中药防治CIS提供理论依据与参考。

Cerebral ischemic stroke(CIS)seriously affects the quality of life of patients due to its high disability rate,high mortality rate and high recurrence rate.Studies have found that traditional Chinese medicine monomer components can prevent and treat CIS through a variety of signaling pathways,such as curcumin,artesunate,baicalin,salvianolic acid D,saikosaponin A,berberine,palmatine,isorhynchophylline,triptolide,astragaloside IV,salidroside,ginsenoside Rgi,dandelionol,peony glycoside and other traditional Chinese medicine monomers can regulate signaling pathway such as nuclear factor kB(NF-kB),high mobility group protein B1(HMGBI),adenosine monophosphate-activated protein kinase(AMPK),mammalian target of rapamycin(mTOR),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),and nuclear transcription factor red lineage 2-related factor 2(Nrf2).The mechanisms related to the effects of monomers from traditional Chinese medicine on the above six signaling pathways were reviewed,in order to provide new ideas and directions for the in-depth study of the prevention and treatment of CIS,and to provide a theoretical basis and reference for the clinical application of traditional Chinese medicine in prevention and treatment of CIS.