益元清肺汤治疗气虚肺热证老年重症肺炎患者的临床效果及对气道重塑、TLR4、sTREM-1水平的影响

Clinical effect of Yiyuan Qingfei decoction in the treatment of elderly patients with severe pneumonia of Qi deficiency and lung heat syndrome and its influences on airway remodeling,TLR4 and sTREM-1 levels

目的探讨益元清肺汤治疗气虚肺热证老年重症肺炎患者的临床效果。方法选取2021年1月至2023年3月收治的100例气虚肺热证老年重症肺炎患者为研究对象,根据随机数字表法将其分为对照组和观察组,各50例。对照组采取常规西药治疗,观察组在对照组基础上加用益元清肺汤治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的转化生长因子-β_(1)(TGF-β_(1))、骨桥蛋白(OPN)、基质金属蛋白酶-9(MMP-9)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的Toll样受体4(TLR4)、可溶性髓样细胞触发受体-1(sTREM-1)水平低于对照组,差异具有统计学意义(P<0.05)。结论益元清肺汤治疗气虚肺热证老年重症肺炎患者的效果显著,可改善气道重塑,抑制TLR4、sTREM-1水平,值得推广。

Objective To explore the clinical effect of Yiyuan Qingfei decoction in the treatment of elderly patients with severe pneumonia of Qi deficiency and lung heat syndrome.Methods A total of 100 elderly patients with severe pneumonia of Qi deficiency and lung heat syndrome admitted from January 2021 to March 2023 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Yiyuan Qingfei decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of transforming growth factor-β_(1)(TGF-β_(1)),osteopontin(OPN)and matrix metalloproteinase-9(MMP-9)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of Toll like receptor 4(TLR4)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Yiyuan Qingfei decoction has a good effect in the treatment of elderly patients with severe pneumonia of Qi deficiency and lung heat syndrome,it can improve airway remodeling and inhibit the levels of TLR4 and sTREM-1,which is worthy of promotion.