蛇毒血凝酶联合奥美拉唑对上消化道出血新生儿凝血功能及应激反应的影响

Effects of snake venom hemagglutinin combined with omeprazole on coagulation function and stress reaction of neonatal with upper gastrointestinal hemorrhage

目的分析蛇毒血凝酶联合奥美拉唑对上消化道出血新生儿凝血功能及应激反应的影响。方法以2021年1月-2023年12月期间接受治疗的70例上消化道出血患儿为观察对象,采用单盲法分组,对照组予以奥美拉唑治疗,观察组予以蛇毒血凝酶联合奥美拉唑治疗,比较各项指标(治疗有效率、凝血指标、应激反应指标、出血停止和隐血试验转阴时间、不良反应)差异。结果观察组治疗有效率高于对照组(P<0.05),1周后观察组APTT、PT短于对照组(P<0.05),FIB高于对照组(P<0.05),MDA低于对照组(P<0.05),SOD高于对照组(P<0.05),出血停止和隐血试验转阴时间短于对照组(P<0.05),两组不良反应发生率无明显区别(P>0.05)。结论上消化道出血新生儿在奥美拉唑治疗基础上应用蛇毒血凝酶可以改善凝血功能,调节APTT、PT、FLB等指标,提高抗应激能力,同时也能尽快止血,药物相关副反应少,促进新生儿病情的恢复。

Objective To analyze the effects of snake venom hemagglutinin combined with omeprazole on coagulation function and stress response of neonatal with upper gastrointestinal hemorrhage.Methods 70 cases of neonatal with upper gastrointestinal hemorrhage treated from January 2021 to December 2023 were divided into two groups by single blind method.The control group was given omeprazole treatment,and the observation group was given snake venom hemagglutinin combined with omeprazole treatment.The differences of various indicators(therapeutic efficiency,coagulation index,stress response index,bleeding stop and occult blood test negative time,adverse reactions)were compared.Results The effective rate of the observation group was higher than that of the control group(P<0.05).After 1 week,APTT and PT in the observation group were shorter than those in the control group(P<0.05),FIB was higher than that in the control group(P<0.05),MDA was lower than that in the control group(P<0.05),SOD was higher than that in the control group(P<0.05),bleeding stop and occult blood test negative time was shorter than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Snake venom hemagglutinin combined with omeprazole in the treatment of neonatal with upper gastrointestinal hemorrhage can improve coagulation function,adjust APTT,PT,FLB and other indicators,improve anti-stress ability,and stop bleeding as soon as possible,with less drug-related side effects,and promote the recovery of neonatal condition.