自身免疫性癫痫

Autoimmune epilepsy

随着免疫检测技术的迅猛发展,越来越多的证据表明免疫是癫痫的致病因素之一。临床医师熟悉自身免疫性癫痫(AE)的临床特征具有重要意义,特别是其在病程早期识别癫痫的免疫性病因并进行及时的免疫治疗对患者的预后非常关键。目前,AE尚无统一的诊治指南,因此本文就AE的发病机制、临床表现、诊断、治疗和预后做简短阐述,为AE的精准诊治提供参考。

With the help of cutting-edge technology such as immunodetection applications,accumulating evidence has implied that immune etiology is involved in the pathogenesis of epilepsy.It is of great significance for clinicians to get familiar with clinical characteristics of autoimmune epilepsy(AE),and the early identification of AE and the timely implementation of targeted immunotherapy are essential to offer best outcome.At present,in the absence of standardized diagnostic and therapeutic guidelines in China,this paper provides a comprehensive update on the current knowledge of the pathogenesis,clinical manifestations,diagnosis,treatment and prognosis of AE,guiding the effective management of AE.