麦粒灸治疗抑郁症的临床研究进展与展望

Progress and Prospect of Clinical Research on Wheat Grain Moxibustion for Depression

抑郁症为临床常见的精神障碍类疾病,极大危害患者身心健康,严重影响患者生活质量。麦粒灸作为古老灸法的一种,目前已逐步应用到防治疗抑郁症,其定位准确、热力渗透强、时间短、收效快,能极大激发人体阳气。麦粒灸在抑郁症的治疗中发挥了上调人体BDNF蛋白表达量,修复和再生海马神经元,抑制炎症反应,激活ERK-Nrf2信号通路等作用,其临床疗效肯定,但临床上需进一步规范麦粒灸操作流程,制定统一疗效评价指标。本文将从麦粒灸治疗抑郁症的中西医理论机制、抑郁症的中西医病因、单纯麦粒灸疗法及麦粒灸联合其他疗法等角度进行综述。

Depression is a commonly seen psychiatric disorder in clinical practice,which greatly jeopardizes the mental and physical health of pa‐tients,seriously affecting their quality of life.Wheat grain moxibustion,as one form of ancient moxibustion therapy,has gradually been applied in the prevention and treatment of depression.It has precise positioning,strong thermal penetration,short duration,and quick effects,which can greatly stimulate the body's yang energy.Wheat grain moxibustion in the treatment of depression has been shown to upregulate the expression of brain derived neurotrophic factor(BDNF)protein in the human body,repair and regenerate hippocampal neurons,inhibit inflammatory responses,and acti‐vate the ERK-Nrf2 signaling pathway.Its clinical efficacy is affirmed,but further standardization of the operating procedures for wheat grain moxi‐bustion and the establishment of uniform evaluation indicators for therapeutic effects are needed in clinical practice.This article provides a compre‐hensive review of the theoretical mechanisms of wheat grain moxibustion in the treatment of depression from the perspectives of both Chinese and Western medicine,the etiology of depression in Chinese and Western medicine,the use of wheat grain moxibustion as a standalone therapy,and the combination of wheat grain moxibustion with other treatment modalities.