梔黄解毒饮对儿童甲型流感症状控制及血清α1-AG、α1-AT、IL-17、IFN-γ水平的影响

Effects of Zhihuang Jiedu drink on control of symptoms and serum α1-AG,α1-AT,IL-17 and IFN-γ of children with influenza A

目的探讨黄解毒饮对儿童甲型流感症状控制及血清αl酸性糖蛋白(α1-AG)、α1l抗胰蛋白酶(α1-AT)、白细胞介素-17(IL-17)、干扰素-γ(IFN-γ)水平的影响。方法依据随机数字表法将2021年1月一2023年1月绵阳市妇幼保健院(绵阳市儿童医院)收治的78例甲型流感患儿分为对照组39例和研究组39例。对照组给予磷酸奥司他韦胶囊,研究组在对照组的基础上给予黄解毒饮,两组均治疗1周。比较两组治疗1周后疗效及症状控制情况,治疗前和治疗1周后免疫功能、血清αl-AG、α1-AT、IL-17、IFN-γ水平及治疗期间不良反应。结果与对照组总有效率(76.92%)比较,研究组治疗1周后的总有效率更高(94.87%,P<0.05)。研究组咳嗽、咽痛、肌肉酸痛、发热、鼻塞流涕消失时间短于对照组(P<0.05)。治疗1周后,两组外周血中性粒细胞与淋巴细胞比值(NLR)、CD_(8)^(+)及血清α1-AG、αl-AT、IL-17、IFN-γ水平与治疗前比较降低,研究组更低(P<0.05);外周血CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,研究组更高(P<0.05)。两组治疗期间的总不良反应发生率比较无统计学差异。结论黄解毒饮可调节甲型流感患儿血清α1-AG、α1-AT、IL-17、IFN-γ水平,减轻机体炎症,并可改善患儿免疫功能,控制症状,进而利于疗效的提高,且并未明显增加患儿的不良反应,安全性良好。

OBJECTIVE To explore the effects of Zhihuang Jiedu Drink on the control of symptoms and serumαl a-cidic glycoprotein(αl-AG),αl antitrypsin(αl-AT),interleukin-17(IL-17)and interferon-γ(IFN-γ)of the chil-dren with influenza A.METHODS A total of 78 children with influenza A who were treated in Mianyang Maternal and Child Care Hospital(Mianyang Children's Hospital)from Jan 2021 to Jan 2023 were enrolled in the study and randomly divided into the control group with 39 cases and the study group with 39 cases.The control group was treated with oseltamivir phosphate capsules,the study group was given additional Zhihuang Jiedu drink on ba-sis of the therapy of the control group,both groups were treated for 1 week.The therapeutic effects and status of control of symptoms were observed and compared between the two groups after the treatment for 1 week.The im-mune function indexes and levels of serumαl-AG,αl-AT,IL-17 and IFN-γ were compared before the treatment and after the treatment for 1 week,and the adverse reactions during the treatment period were observed.RESULTS The total effective rate of the study group was 94.87%after the treatment for 1 week,higher than 76.92%of the control group(P<0.05).The time of disappearance of cough,pharyngalgia,muscular soreness,fever and nasal congestion and runny nose was shorter in the study group than in the control group(P<0.05).The peripheral blood neutrophils to lymphocytes ratio(NLR),CD+,and levels of serumαl-AG,αl-AT,IL-17 and IFN-γ of the two groups were lower after the treatment for 1 week than before the treatment,and the levels of the above indexes of the study group were lower than those of the control group(P<0.05).The levels of peripheral blood CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)of the two groups were elevated,and the levels of the above indexes of the study group were higher(P<o.05).There was no significant difference in the total incidence of adverse reactions between the two groups during the treatment period.CONCLUSION Zhihuang Jiedu drink can regulate the levels of serumαl-AG,al-AT,IL-17 and IFN-γ of the children with influenza A,alleviate the inflammatory response,improve the immune function,and control the symptoms so as to boost the therapeutic effect without a significant increase of adverse reactions,with the safety favorable.