化疗导致周围神经病变及针刺干预机制探讨

Exploration of Chemotherapy-induced Peripheral Neuropathy and Mechanism of Acupuncture Intervention

当前癌症发病率日渐升高,治疗手段虽不断进步,但化疗作为癌症治疗的重要基石仍在肿瘤防治中起到重要作用。多种化疗药物可造成急慢性周围神经损伤,其中以铂类及紫杉烷类药物为主,周围神经损伤可严重影响患者生存质量及临床治疗,目前仍无确切有效的治疗方案。现有多项临床研究提示针灸对于化疗引起的周围神经损伤具有改善作用,但其机制尚不明确,本文依据目前现有研究从改善氧化应激、抑制神经炎性反应、调节镇痛相关神经递质、调节离子通道等方面探讨化疗导致周围神经病变及针灸干预的机制。

Currently,the incidence of cancer is increasing day by day,and although the treatment means are con-stantly deepening,chemotherapy,as an important cornerstone of cancer treatment,still plays an important role in the prevention and treatment of tumors.A variety of chemotherapeutic drugs can cause acute and chronic peripheral nerve injury,mainly platinum and paclitaxel,peripheral nerve injury can seriously affect the quality of survival of patients and clinical treatment,and there is still no accurate and effective treatment program.A number of clinical studies have suggested that acupuncture has an ameliorative effect on chemotherapy-induced peripheral nerve injury,but its mechanism is not clear.This paper would like to discuss the mechanism of chemotherapy-induced peripheral neuropa-thy and acupuncture intervention from the aspects of improving oxidative stress,inhibiting neuroinflammatory re-sponse,regulating analgesic-related neurotransmitters,and regulating ion channels based on the existing studies.