养元健骨汤联合常规补钙对老年股骨粗隆间骨折髓内钉术后患者骨密度及骨折愈合速度的影响

Effect of Yangyuan Jiangu Decoction Combined with Routine Calcium Supplementation on Bone Mineral Density and Fracture Healing Speed in Elderly Patients with Intertrochanteric Fracture After Intramedullary Nail Surgery

目的 探讨养元健骨汤联合常规补钙对老年股骨粗隆间骨折髓内钉术后患者骨密度及骨折愈合速度的影响。方法 选取医院2018年1月至2022年2月收治的老年股骨粗隆间骨折行髓内钉术的患者90例,按随机数字表法分为常规补钙组和养元健骨汤组,各45例。两组患者术后均予常规补钙治疗,养元健骨汤组患者加用养元健骨汤,均持续治疗1个月。结果 养元健骨汤组总有效率为93.33%,显著高于常规补钙组的73.33%(P <0.05)。治疗后,两组患者的骨代谢指标β胶联降解产物含量均显著减少(P <0.05),Ⅰ型胶原氨基端肽原、血清骨钙素含量均显著增加(P <0.05),且养元健骨汤组均显著优于常规补钙组(P <0.05);两组患者的Harris髋关节功能评分量表(HHS)评分、骨密度均显著升高(P <0.05),且养元健骨汤组均显著高于常规补钙组(P <0.05);养元健骨汤组患者的股骨骨折愈合时间显著短于常规补钙组(P <0.05)。养元健骨汤组和常规补钙组不良反应发生率相当(6.67%比4.44%,P> 0.05)。结论 养元健骨汤联合常规补钙治疗老年股骨粗隆间骨折髓内钉术后的临床疗效良好,能增加患者的骨密度,加快骨折愈合速度,且安全性良好。

Objective To investigate the effect of Yangyuan Jiangu Decoction combined with routine calcium supplementation onbone mineral density and fracture healing speed in elderly patients with intertrochanteric fracture after intramedullary nail surgery.Methods A total of 90 elderly patients who underwent intramedullary nail surgery for intertrochanteric fracture of the femuradmitted to the hospital from January 2018 to February 2022 were selected and divided into the routine calcium supplementationgroup and the Yangyuan Jiangu Decoction group by the random number table method,with 45 cases in each group.The patients inthe two groups were treated with routine calcium supplementation after surgery,while the patients in the Yangyuan Jiangu Decoctiongroup received additional treatment with Yangyuan Jianggu Decoction.Both groups were treated for one month.Results The totaleffective rate in the Yangyuan Jiangu Decoction group was 93.33%,which was significantly higher than 73.33% in the routinecalcium supplementation group(P < 0.05).After treatment,the content of bone metabolism indexes such as β-collagendegradation products(β-CTX) in the two groups significantly decreased(P < 0.05),while the levels of procollagen type Ⅰ amino terminal peptide(PⅠNP) and serum osteocalcin(OC) in the two groups significantly increased(P < 0.05),and those inthe Yangyuan Jiangu Decoction group were significantly better than those in the routine calcium supplementation group(P < 0.05).The Harris Hip Scale(HHS) score and bone mineral density(BMD) in the two groups significantly increased(P < 0.05),andthose in the Yangyuan Jiangu Decoction group were significantly higher than those in the routine calcium supplementation group(P < 0.05).The femoral fracture healing time in the Yangyuan Jiangu Decoction group was significantly shorter than that in theroutine calcium supplementation group(P < 0.05).The incidence of adverse reactions was comparable between the YangyuanJiangu Decoction group and the routine calcium supplementation group(6.67% vs.4.44%,P > 0.05).Conclusion YangyuanJiangu Decoction combined with routine calcium supplementation has good efficacy and safety in the treatment of elderly patientswith intertrochanteric fractures after intramedullary nail surgery,which can increase the patient′s BMD and fracture healing speed.