替吉奥胶囊姑息治疗晚期消化道肿瘤的临床探究

Clinical Exploration of Tegio Capsules in Palliative Treatment of Late-Stage Gastrointestinal Tumors

目的替吉奥胶囊姑息治疗晚期消化道肿瘤的临床探究。方法选择2022年10月至2024年4月河南大学第一附属医院收治的68例晚期消化道肿瘤患者作为研究对象,随机数表法分作常规组与研究组,各34例。常规组患者采用常规姑息治疗,研究组在姑息治疗基础上服用替吉奥胶囊,评价两组患者的治疗效果及血管内皮生长因子(VEGF)水平、肿瘤异常蛋白(TAP)凝聚物面积,统计并比较两组患者不良反应发生情况。结果开展为期两个疗程的治疗后,研究组患者的治疗有效率优于常规组,差异具有统计学意义(P<0.05);研究组患者不良反应发生率低于常规组,差异具有统计学意义(P<0.05)。治疗后,研究组患者VEGF水平和TAP凝聚物面积低于常规组,差异具有统计学意义(P<0.05)。结论合理运用替吉奥胶囊姑息治疗方案治疗晚期消化道肿瘤患者,能够提升肿瘤控制率,有利于降低患者不良反应率,并且通过对VEGF与TAP进行检测,有助于了解患者治疗效果,值得应用。

Objective To explore the clinical application of Tegio capsules in palliative treatment of late-stage gastrointestinal tumors.Methods 68 patients with late-stage gastrointestinal tumors treated in The First Affiliated Hospital of Henan University from October 2022 to April 2024 were selected as the research subjects.They were divided into a routine group and a research group,each with 34 cases,according to the random number table method.The routine group patients received routine palliative treatment,and the research group patients took Tegio capsules on the basis of palliative treatment.The treatment effects of the two groups of patients and the levels of vascular endothelial growth factor(VEGF)and tumor abnormal protein(TAP)agglomerate area were evaluated,and the occurrence of adverse reactions in the two groups of patients was statistically compared.Results After two courses of treatment,the effective rate of treatment in the research group was higher than that in the routine group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the research group was lower than that in the routine group,and the difference was statistically significant(P<0.05).After treatment,the VEGF level and TAP agglomerate area of the research group patients were lower than those of the routine group,and the difference was statistically significant(P<0.05).Conclusion The reasonable use of Tegio capsules in the palliative treatment plan for patients with late-stage gastrointestinal tumors can improve the tumor control rate,help reduce the incidence of adverse reactions in patients,and the detection of VEGF and TAP can help understand the treatment effect of patients,which is worth applying.