雷珠单抗联合视网膜黄斑区格栅光凝治疗糖尿病视网膜病变黄斑水肿的临床效果

Clinical Effect of Ranibizumab Combined with Retinal Macular Grid Photocoagulation in the Treatment of Diabetic Retinopathy Macular Edema

目的探讨糖尿病视网膜病变黄斑水肿患者应用玻璃体腔注射雷珠单抗联合视网膜黄斑区格栅光凝的治疗效果。方法纳入2019年1月至2021年12月间河南省濮阳市范县复明医院收治的60例糖尿病视网膜病变黄斑水肿患者,采用随机数字表法将患者分为对照组、观察组,各30例。对照组患者给予视网膜黄斑区格栅光凝治疗,观察组患者同时联合玻璃体腔注射雷珠单抗治疗。对两组患者治疗后的临床疗效,不同时间点(治疗后1个月、治疗后6个月)裸眼视力、黄斑区视网膜厚度、眼压情况进行比较。结果观察组患者在治疗6个月后临床疗效优于对照组,差异无统计学意义(P>0.05)。治疗后观察组患者各时间点裸眼视力检测高于对照组,差异具有统计学意义(P<0.05)。各时间点观察组患者黄斑区视网膜厚度检测数据低于对照组,差异具有统计学意义(P<0.05)。各时间点观察组患者眼压检测数据低于对照组,差异无统计学意义(P>0.05)。结论对糖尿病视网膜病变患者进行玻璃体腔注射雷珠单抗联合视网膜黄斑区格栅光凝治疗较单一激光光凝手术治疗临床疗效佳,可帮助患者术后更好恢复视力,加快对黄斑水肿的吸收速度,降低对患者生活的影响。

Objective To explore the therapeutic effect of intravitreal injection of ranibizumab combined with retinal macular grid photocoagulation in patients with diabetic retinopathy macular edema.Methods From January 2019 to December 2021,60 patients with diabetic retinopathy macular edema treated in Fuming Hospital of Fan County,Puyang City,Henan Province were included.The patients were divided into a control group and an observation group,each with 30 cases,using a random number table method.The control group was treated with retinal macular grid photocoagulation,and the observation group was treated with intravitreal injection of ranibizumab combined with retinal macular grid photocoagulation.The clinical efficacy after treatment,naked eye vision,macular retinal thickness,and intraocular pressure at different time points(1 month and 6 months after treatment)were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group 6 months after treatment,but the difference was not statistically significant(P>0.05).After treatment,the naked eye vision of the observation group at each time point was higher than that of the control group,and the difference was statistically significant(P<0.05).The macular retinal thickness of the observation group at each time point was lower than that of the control group,and the difference was statistically significant(P<0.05).The intraocular pressure of the observation group at each time point was lower than that of the control group,but the difference was not statistically significant(P>0.05).Conclusion The clinical effect of intravitreal injection of ranibizumab combined with retinal macular grid photocoagulation in the treatment of patients with diabetic retinopathy is better than that of single laser photocoagulation surgery.It can help patients recover their vision better after surgery,accelerate the absorption of macular edema,and reduce the impact on patients’lives.