载药微球联合TACE治疗原发性肝癌患者的效果观察

Efficacy of Drug-loaded Microspheres Combined with TACE in the Treatment of Primary Liver Cancer

目的观察载药微球联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌患者的效果。方法选取2021年6至12月收治的原发性肝癌患者60例,根据患者住院序号分为研究组和对照组各30例。研究组采用TACE联合CalliSpheres载药微球治疗,对照组接受传统TACE治疗。观察2组临床疗效、血常规、肝功能指标、甲胎蛋白(AFP)水平,并评估安全性。结果2组治疗后血红蛋白、血小板计数、白蛋白较治疗前降低,总胆红素、丙氨酸转氨酶、天冬氨酸转氨酶较治疗前升高(P<0.05);2组治疗后1周上述指标比较差异无统计学意义(P>0.05)。研究组治疗后AFP水平低于对照组(P<0.05)。研究组并发症及毒副反应发生率低于对照组(P<0.05)。研究组总有效率[86.67%(26/30)]高于对照组[63.33%(19/30)](P<0.05)。研究组术后1、2年的总体生存与局部控制率均高于对照组(P<0.05)。研究组满意度评分[(79.14±16.37)分]高于对照组[(64.35±17.22)分](P<0.01)。结论载药微球联合TACE治疗原发性肝癌效果较好,可有效延长患者生存时间,减轻并发症及毒副反应,提高生存质量。

Objective To observe the effect of drug-loaded microspheres combined with transhepatic artery chemoem-bolization(TACE)in the treatment of patients with primary liver cancer(PLC).Methods From June to December 2021,60 pa-tients with PLC were selected and divided into research group and control group according to the hospitalization number of the patients.The research group was treated with TACE combined with CalliSpheres drug-loaded microsphere,and the control group was treated with conventional TACE.Clinical efficacy,blood routine,liver function indicators,andα-fetoprotein(AFP)levels were observed,and safety was assessed.Results After treatment,hemoglobin,platelet count,and albumin decreased,as com-pared with those before treatment,while total bilirubin,alanine transaminase,and aspartate transaminase increased(P<0.05).However,there was no statistically significant difference in above indicators between the two groups at one week after surgery(P>0.05).The AFP level in the research group after treatment was lower than that in the control group(P<0.05).The compli-cations and toxic and side effects in the research group were lower than those in the control group(P<0.05).The total effective rate was higher in the research group than in the control group[86.67%(26/30)vs.63.33%(19/30)](P<0.05).The 1-,2-year overall survival rates and local control rate of the research group were higher than those of the control group(P<0.05).The satisfaction score of the research group[(79.14±16.37)points]was higher than that of the control group[(64.35±17.22)points](P<0.01).Conclusion The combination of drug-loaded microspheres and TACE is effective in the treatment of PLC,which can effectively prolong the survival of patients,reduce complications and toxic and side effects and improve the quality of life.