肿瘤干细胞在肿瘤治疗中的应用研究进展

Application and progress of tumor stem cells in tumor therapy

肿瘤干细胞是一类具有自我更新与复制分化能力的干细胞,在肿瘤组织中占比极小,却能够影响肿瘤发生、发展和复发过程,对肿瘤异质性起着至关重要的作用。因此,在肿瘤的治疗过程中,肿瘤干细胞也必须被纳入考虑。肿瘤干细胞不仅可以通过多种信号通路、基因调节和细胞间的相互作用来维持自身的干细胞特性,同时还能够促进肿瘤细胞的增殖、侵袭和转移,故成为肿瘤治疗中的重要靶点。此外,肿瘤干细胞的微环境也影响着肿瘤的复发、耐药、转移等过程。综上,本文从肿瘤干细胞出发,通过描述肿瘤干细胞的相关信号通路,对靶向肿瘤干细胞的相关治疗手段,如免疫疗法、促分化疗法与miRNA疗法作以综述,以期为肿瘤治疗提供新思路。

Cancer stem cells are a subset of cells with self-renewal,replication and differentiation abilities,accounting for a small proportion in tumor tissue.However,they can influence the process of tumor occurrence,development,and recurrence,playing a crucial role in tumor heterogeneity.Therefore,in order to completely cure tumors,treatment targeting cancer stem cells must be considered.Cancer stem cells can maintain their own stem cell characteristics through different signaling pathways,gene regulation,and cell interactions,while also promoting tumor cell proliferation,invasion,and metastasis,so it becomes an important target in tumor therapy.The microenvironment of cancer stem cells has a significant impact on tumor occurrence and development,including recurrence,drug resistance,metastasis and other events.In summary,starting from tumor stem cells and describing the relevant signaling pathways of tumor stem cells,this paper reviews the relevant therapies targeting cancer stem cells,such as immunotherapy,pro-differentiation therapy,and miRNA therapy,in order to provide new ideas for tumor therapy.