磁场和超声波共同作用下磁性微球的深度聚集

Deep accumulation of magnetic microspheres under the combined action of magnetic field and ultrasonic wave

在磁性药物靶向治疗中,由于普通电磁铁产生的磁场的磁通密度会随距离衰减,造成磁性药物颗粒在离磁极较近的部位聚集较多,而在离磁极较远的部位聚集较少,这限制了磁靶向技术在深度组织部位的应用.提出了环形磁极磁场和超声波声场相结合的非侵入性新方法,以实现磁性微粒的三维深度聚集.首先,给出深度聚集磁性微粒实验设备的结构设计;然后,利用COMSOL仿真软件计算出实现深度聚集的超声波振幅范围;最后,依据仿真结果给出的参数进行了实验.实验结果证明,在合适的超声波强度下,磁性微球在远离磁极区域的聚集量多于离磁极较近区域,实现了磁性微粒在三维方向的深度聚集.

In magnetic drug targeting(MDT),a large quantity of magnetic drug particles is absorbed near the magnetic pole,with only a small number of those adsorbed far away from the magnetic pole,where the magnetic field produced by the general electromagnet is attenuated,hindering MDT applications in deep tissue.In this paper,we propose a new noninvasive approach,in which the magnetic field is combined with ultrasound to achieve three-dimensional deep accumulation of magnetic particles.First,the structure design of the experimental equipment for deep aggregation of magnetic particles is presented.Second,the range of ultrasonic amplitudes that can achieve deep aggregation is calculated using the COMSOL simulation software.Finally,an experiment is performed based on simulations and experimental results show that the quantity of magnetic microspheres absorbed in areas far from the magnetic poles is more than those in areas close to the magnetic pole,thereby demonstrating that deep aggregation of magnetic particles was achieved.