柑橘类水果中的抗癌活性成分及其机制研究进展

Research Progress on Anticancer Components in Citrus and Their Action Mechanisms

目前,癌症是仅次于心血管疾病的第二大死因。尽管有许多不同的癌症治疗方法,但都有严重的副作用和耐药性。因此,科学家们正在寻找能够有效预防癌症发生的天然产物。研究表明食用柑橘类水果可降低包括癌症在内的多种疾病的患病风险,其抗癌作用可归因于多种生物活性成分。本文系统总结了国内外研究现状,主要综述了柑橘类水果及其主要活性成分发挥抗癌效应的研究进展,并对其相应分子机制进行了详细阐述归纳。柑橘作为具有高药用价值的重要水果之一,深入研究其抗癌功效及其分子机理将有助于其产业价值的提升,并为将柑橘类水果加工开发成具有化学预防癌症的功能性食品提供理论基础。随着柑橘类水果中的抗癌活性成分和抗癌作用机理研究的日趋明朗,其作为抗癌天然产物来源运用于临床癌症治疗指日可待。

Cancer is now the second leading cause of death after cardiovascular diseases.Although there are many different cancer treatments available,all of them have serious side effects and drug resistance.Therefore,scientists are searching for natural products that can effectively prevent the occurrence of cancers.Studies have shown that the consumption of citrus fruits can reduce the risk of several diseases,including cancers,and its anti-cancer effects are attributed to a variety of bioactive ingredients.This article systematically summarizes recent progress in research on the major anti-cancer ingredients in citrus fruits and their molecular mechanisms.Citrus is one of the important fruits with high medicinal value.In-depth studies on its anti-cancer effects and molecular mechanisms will help to enhance its industrial value,and provide a theoretical basis for the processing and development of citrus fruits into functional foods for chemical prevention of cancers.As the anti-cancer constituents and mechanisms of citrus fruits have been understood fully,their application as a natural source of anti-cancer agents in clinical cancer treatments can be expected soon.