线粒体动力学及线粒体自噬调控机制在心血管疾病中的研究进展

Research Progress of Regulation Mechanism of Mitochondrial Dynamics and Mitophagy in Cardiovascular Diseases

线粒体动力学及线粒体自噬是线粒体质量控制的两种重要途径,对维持线粒体正常功能至关重要,且线粒体动力学与线粒体自噬之间存在复杂的动态调控网络。心脏收缩需要大量ATP提供能量,因此线粒体质量对于维持正常的心血管功能至关重要。目前认为,线粒体融合与分裂的失衡、线粒体自噬的异常在多种心血管疾病的病理机制中发挥重要作用。因此,深入探讨线粒体动力学及线粒体自噬的分子机制、相互调控关系及其在心血管疾病中的作用可为心血管疾病的防治提供新思路。

Mitochondrial dynamics and mitophagy are two important pathways for mitochondrial quality control,which are crucial for maintaining normal mitochondrial function,and there is a complex dynamic regulatory network between mitochondrial dynamics and mitophagy.Cardiac contraction requires a large amount of ATP to provide energy,so mitochondrial mass is crucial for maintaining normal cardiovascular function.Currently,it is believed that the imbalance between mitochondrial fusion and division,as well as abnormal mitophagy,play important roles in the pathological mechanisms of various cardiovascular diseases.Therefore,in-depth exploration of the molecular mechanisms and mutual regulatory relationships between mitochondrial dynamics and mitophagy,as well as their roles in cardiovascular diseases,can provide new ideas for the prevention and treatment of cardiovascular diseases.