线粒体融合蛋白2在缺血再灌注损伤中作用的研究进展

Research Progress of Role of Mitofusin 2 in Ischemia-Reperfusion Injury

线粒体融合蛋白2(Mfn2)介导线粒体融合与分裂过程,参与调控线粒体动力学,是线粒体形态、结构和功能的动力素相关蛋白。缺血再灌注损伤(IRI)是外科手术中一种常见的并发症,也是创伤性休克、严重感染等致命疾病的主要死亡原因。近年来发现,Mfn2在IRI中具有修复作用,包括肠IRI、肺IRI、肾IRI和心脏IRI等。Mfn2通过多个途径参与不同IRI的修复,减缓疾病进展。深入研究Mfn2与IRI的关系及相关机制,可为IRI的防治提供新的靶点和思路。

Mitofusin 2(Mfn2)mediates mitochondrial fusion and lysis and is involved in the regulation of mitochondrial dynamics.It is a dynamin-related protein of mitochondrial morphology,structure and function.Ischemia-reperfusion injury(IRI)is a common surgical complication and the main cause of death in fatal diseases such as traumatic shock and severe infection.In recent years,it is found that Mfn2 has a repairing effect in a variety of IRI,including intestinal IRI,lung IRI,kidney IRI,and heart IRI.Mfn2 is involved in the repair of different IRI through multiple pathways and slows disease progression.In-depth study of the relationship between Mfn2 and IRI and its related mechanisms may provide new targets and ideas for the prevention and treatment of IRI.