中医药通过肠道菌群影响胆汁酸代谢治疗脂肪肝的研究进展

Research progress in the treatment of fatty liver by the effect of traditional Chinese medicine on bile acid metabolism through intestinal flora

目前脂肪肝是严重威胁人类健康的第一大肝病,但没有公认的治疗方案。有研究发现肠道菌群及胆汁酸与脂肪肝的发生、发展密切相关。中医药治疗脂肪肝取得了一定的研究进展。本文将从以下6个方面综述中医药通过肠道菌群影响胆汁酸代谢治疗脂肪肝的机制:改善糖、脂代谢;调节胆汁酸转运蛋白的表达;促进肠道干细胞增殖分化保护肠道屏障功能;促进自噬,减少活性氧的蓄积;调节巨噬细胞的分化;促进胆囊收缩降低血浆胆固醇。为进一步研究脂肪肝的治疗提供参考。

At present,fatty liver disease is the first major liver disease that seriously threatens human health,but there is no recognized treatment scheme.Research have found that intestinal flora and bile acids are closely related to the occurrence and development of fatty liver disease.Traditional Chinese medicine and pharmacy has made certain research progress in the treatment of fatty liver disease.It will be summarized in this paper that the mechanism of traditional Chinese medicine and pharmacy in the treatment of fatty liver is impacting bile acid metabolism through intestinal flora from the following six aspects,which are:Improving glucose and lipid metabolism.Regulating the expression of bile acid transporter.Promoting the proliferation and differentiation of intestinal stem cells and protecting the intestinal barrier function.Increasing autophagy and reducing the accumulation of reactive oxygen species.Adjusting the differentiation of macrophages.Stimulating gallbladder contraction and lowering plasma cholesterol.Reference for further research in the treatment of fatty liver disease is provided.