血清FFA、IL-37和Lp-PLA2与2型糖尿病患者血管内皮损伤的相关性研究

Study on correlation between serum FFA,IL-37 and Lp-PLA2 and vascular endothelial injury in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(T2DM)患者血清中游离脂肪酸(FFA)、白细胞介素-37(IL-37)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平变化与血管内皮损伤的相关性。方法本研究选取山东第一医科大学第二附属医院(本院)2023年1—6月收治T2DM患者113例为T2DM组(试验组),选择同期在本院健康查体者113名为健康组(对照组),检测两组的血脂指标、血糖指标及血管内皮损伤指标进行统计分析。结果T2DM组的空腹血糖(FPG)、游离脂肪酸(FFA)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、低密度脂蛋白(LDL)、IL-37及Lp-PLA2水平均高于健康组,一氧化氮(NO)水平低于健康组,差异有统计学意义(P<0.05);两组总胆固醇(TC)、高密度脂蛋白(HDL)比较,差异无统计学意义(P>0.05)。T2DM组FFA、IL-27和Lp-PLA2水平与NO的降低水平均呈正相关(P<0.05)。以NO为T2DM血管内皮是否损伤的标准进行ROC曲线分析,IL-37、Lp-PLA2及FFA的AUC和95%CI均高于其他检测指标且差异有统计学意义(P<0.05)。结论T2DM患者血清中FFA、IL-37及Lp-PLA2等指标显著表达,NO水平显著降低与血管内皮损伤具有相关性,对T2DM血管病变的预测和筛查具有重要的临床意义。

Objective To investigate the correlation between the changes of serum free fatty acid(FFA),interleukin--37(IL--37)and lipoprotein-associated phospholipase A2(Lp-PLA2)and vascular endothelial injury in patients with type 2 diabetes mellitus(T2DM).Methods A total of 113 T2DM patients admitted to the Second Affiliated Hospital of Shandong First Medical University(our hospital)from January to June 2023 were selected as the T2DM group(experimental group),and 113 patients with.healthy physical examination results in our hospital during the same period were selected as the healthy group(control group).The blood lipid index,blood glucose index and vascular endothelial injury index of the two groups were detected and statistically analyzed.Results The levels of fasting blood glucose(FPG),free fatty acids(FFA),glycated hemoglobin(HbA1c),triglycerides(TG),low-density lipoprotein(LDL),IL-37,and Lp-PLA2 in the T2DM group were higher than those in the healthy group,while the levels of nitric oxide(NO)were lower than those in the healthy group..with statistical significance(P<0.05).There was no statistically significant difference in total cholesterol(TC)and high-density lipoprotein(HDL)between the two groups(P>0.05).The levels of FFA,IL-27,and Lp-PLA2 in the T2DM group were positively correlated with the decrease in NO level(P<0.05).ROC curve analysis was performed using NO as the criterion for endothelial injury in T2DM.The AUC and 95%CI of IL-37,Lp-PLA2,and FFA were higher than other detection indicators and the differences were statistically significant(P<0.05).Conclusion FFA,IL-37 and Lp-PLA2,signifieantly reduced NO level,correlated with vaseular endothelial injury and have important clinical significance for the prediction and screening of T2DM vascular lesions.