SAA、IL-6、CRP及T淋巴细胞亚群联合检测在类风湿性关节炎患者中的应用价值

Application value of combined detection of SAA,IL-6,CRP and T lymphocyte subsets in patients with rheumatoid arthritis

目的探讨血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)、C反应蛋白(CRP)及T淋巴细胞亚群联合检测在类风湿性关节炎患者中的应用价值并进行相关危险因素分析。方法选取2020年10月至2023年5月在玉林市第一人民医院确诊为类风湿性关节炎的患者66例为类风湿关节炎组,同期选择体检健康者33名为对照组,比较两组SAA、IL-6、CRP及T淋巴细胞亚群水平的差异。结果类风湿性关节炎组SAA、IL-6、CRP、CD3^(+)T%及CD4^(+)T%水平高于对照组,CD8^(+)T%水平低于对照组,差异有统计学意义(P<0.05)。Spearman相关分析结果显示,IL-6与SAA、CRP、CD3^(+)T%及CD4^(+)T%呈正相关(P<0.05);CD4^(+)T%与SAA、IL-6、CRP、CD3^(+)T%呈正相关(P<0.05);IL-6、CD4^(+)T%分别与CD8^(+)T%呈负相关(P<0.05)。二元logistic回归分析显示,SAA、IL-6、CRP、CD3^(+)T%及CD4^(+)T%是类风湿性关节炎患者的危险因素,而CD8^(+)T%是该类患者保护因素(P<0.05)。结论类风湿性关节炎患者SAA、IL-6、CRP是类风湿性关节炎患者的危险因素,T淋巴细胞亚群免疫异常与该疾病发生发展密切相关,多项目联合检测对类风湿性关节炎临床诊疗及评估病情有重要价值。

Objective To investigate the application value of combined detection of serum amyloid A(SAA),interleukin-6(IL-6),C-reactive protein(CRP)and T lymphocyte subsets in patients with rheumatoid arthritis,so as to analyze the related risk factors.Methods Patients with rheumatoid arthritis diagnosed in the First People’s Hospital of Yulin from October 2020 to May 2023 were selected as the rheumatoid arthritis group(n=66),while healthy people were selected as the control group(n=33).The differences of SAA,IL-6,CRP and T lymphocyte subsets between the two groups were compared.Results The levels of SAA,IL-6,CRP,CD3^(+)T%and CD4^(+)T%were higher in the rheumatoid arthritis group than in the control group,while the level of CD8^(+)T%were lower than in the control group,with statistically significant differences(P<0.05).The Spearman correlation analysis results showed that IL-6 was positively correlated with SAA,CRP,CD3^(+)T%and CD4^(+)T%(P<0.05).CD4^(+)T%was positively correlated with SAA,IL-6,CRP and CD3^(+)T%(P<0.05).IL-6 and CD4^(+)T%were negatively correlated with CD8^(+)T%,respectively(P<0.05).Binary logistic regression analysis showed that SAA,IL-6,CRP,CD3^(+)T%and CD4^(+)T%were the risk factors of patients with rheumatoid arthritis,while CD8^(+)T%was the protective factor for the patient(P<0.05).Conclusion The levels of SAA,IL-6,CRP in patients with rheumatoid arthritis are risk factors for those with rheumatoid arthritis,and the immune abnormality of T lymphocyte subsets is closely related to the occurrence and development of the disease.Multi-item combined detection is of great value for clinical diagnosis,treatment and evaluation of rheumatoid arthritis.