Rho/ROCK通路与心律失常的研究进展

Rho/ROCK Pathway and Arrhythmia

越来越多的证据表明,Rho/ROCK通路在不同程度上调控着细胞的生长、发育、迁移、增殖和死亡,并在各种疾病中发挥重要作用。此外,Rho/ROCK通路与成纤维细胞、Ca^( 2+)和炎症因子等的相互作用对肺动脉高压和心血管疾病的发生与发展产生了重要的影响。近年来Rho/ROCK通路在心律失常中发挥的作用备受关注,现通过总结相关研究,为抗心律失常药的研究提供进一步参考。

Numerous evidence shows that Rho/ROCK pathway regulates cell growth,development,migration,proliferation and death to varying degrees,and plays an important role in various diseases.In addition,the interaction of Rho/ROCK pathway with fibroblasts,calcium ions and inflammatory factors has an important impact on the occurrence and development of pulmonary hypertension and cardiovascular diseases.In recent years,the role of Rho/ROCK pathway in arrhythmia has attracted much attention,and relevant studies are summarized to provide further research reference for antiarrhythmic drugs.