代谢重塑在射血分数保留的心力衰竭中的研究进展

Metabolic Remodeling in Heart Failure with Preserved Ejection Fraction

临床上将射血分数保留的心力衰竭(HFpEF)定义为伴有心力衰竭症状和体征且左室射血分数≥50%的一种心力衰竭类型,表现为HFpEF相关的心脏结构/功能的异常,如左心室肥大、左心房扩大和舒张功能障碍,且往往合并症多,是由多种致病因素共同导致的结果。尽管目前对HFpEF的发病机制认识仍不足,但是存在共同的致病通路,最终导致该疾病的发生发展,这主要与代谢重塑有关。现对代谢重塑在HFpEF中分子机制的研究进展综述如下。

In clinical practice,heart failure with preserved ejection fraction(HFpEF)is defined as a type of heart failure with accompanying symptoms and signs of heart failure and left ventricular ejection fraction≥50%.It is characterized by abnormalities in heart structure/function related to HFpEF,such as left ventricular hypertrophy,left atrial enlargement and diastolic dysfunction,often with multiple comorbidities.It is the result of multiple pathogenic factors working together.At present,the understanding of the pathogenesis of HFpEF is still insufficient,but there are still common pathogenic pathways that ultimately lead to the occurrence and development of the disease.This is mainly related to metabolic remodeling.The research progress on the molecular mechanism of metabolic remodeling in HFpEF is summarized as follows.