头颈癌治疗诱发的淋巴水肿:临床因素和预后分析

Head and neck cancer therapy-induced lymphedema:clinical factors and prognostic analysis

目的:探讨头颈部恶性肿瘤患者淋巴水肿的严重程度与其相关临床数据之间的关系。方法:对接受多模式治疗的79例头颈癌患者进行回顾性研究。基于术后6个月以上的磁共振成像结果进行淋巴水肿诊断和分级,通过查阅电子病历和电话随访获取相关信息。采用SPSS 26.0软件包对数据进行统计学分析。结果:随着TNM分期、颈淋巴清扫范围的增加,患者淋巴水肿重度率增加。术前接受药物诱导化疗的患者与未接受化疗的患者相比,淋巴水肿重度率更高。不同严重水肿程度患者无瘤生存期无统计学差异。结论:头颈部淋巴水肿的发生与肿瘤分期、淋巴清扫的程度以及综合治疗方式有一定相关性,仍需进一步关注和研究。

PURPOSE:To analyze the correlation between the severity of lymphedema in patients with head and neck malignancies and relevant clinical data related to the tumors.METHODS:In this paper,a retrospective study was conducted on 79 patients with head and neck cancer who received multimodality treatment.The diagnosis and grading were conducted by MRI results of patients more than 6 months after surgery,and the electronic records and telephone follow-up data were utilized.SPSS 26.0 software package was used for data analysis.RESULTS:As TNM stage increased and the extent of cervical lymph node dissection expanded,the incidence rate of severe lymphedema in patients also rose.Com-pared to patients who did not receive chemotherapy before surgery,those who underwent preoperative drug-induced chemotherapy had a higher prevalence of severe lymphedema.However,there was no significant difference in the dis-ease-free survival period among patients with varying degrees of severity of lymphedema.CONCLUSIONS:Head and neck lymphedema correlates with tumor stage,extent of lymphatic clearance,and comprehensive treatment modalities.However,further research and attention are still needed.