输血相关性急性肺损伤患者血清MUC1和CD5L水平及预后预测价值

Levels of serum MUC1 and CD5L in patients with transfusion-related acute lung injury and their prognostic value

目的:分析黏蛋白1(MUC1)和CD5抗原样蛋白(CD5L)在输血相关性急性肺损伤患者中的血清水平及其预后影响因素,探讨MUC1、CD5L血清水平对患者预后的预测价值。方法:回顾性选取2021年8月—2023年6月期间于张家口市第一医院治疗的132例输血相关性急性肺损伤患者作为研究对象,根据患者预后情况划分为预后良好组(87例)和预后不良组(45例),同时收集两组患者的一般临床资料。酶联免疫吸附试验法检测两组患者血清MUC1、CD5L水平;χ^(2)检验或t检验对比两组患者的一般临床资料和血清水平;R语言cor函数分析两血清水平与患者预后之间的相关性;多因素Logistic回归分析患者预后的影响因素,并采用受试者工作特性(ROC)曲线分析MUC1、CD5L血清水平对患者预后的预测价值。结果:预后不良组患者的疾病严重程度、血糖和MUC1血清水平显著高于预后良好组,CD5L血清水平则与此相反(均P<0.05)。患者的MUC1和CD5L血清水平之间、CD5L水平与预后之间为显著负相关关系,MUC1与预后的相关性与此相反(均P<0.05)。Logistic回归分析表明,CD5L血清水平为患者预后不良的保护因素,APACHEⅡ评分和MUC1血清水平为患者预后不良的危险因素(均P<0.05)。ROC曲线分析表明,MUC1和CD5L血清水平可以作为输血相关性急性肺损伤患者预后的预测指标,两血清水平联合的预测价值更高(P<0.05)。结论:输血相关性急性肺损伤患者的MUC1、CD5L血清水平与患者预后密切相关,二者联合对输血相关性急性肺损伤患者的预后具有较高的预测价值。

Objective:To analyze the levels of serum mucin 1(MUC1)and CD5 antigen like protein(CD5L)in patients with transfusion related acute lung injury and their prognostic factors,and to explore the predictive value of serum MUC1 and CD5L levels for prognosis.Methods:A retrospective study was conducted on 132 patients with transfusion-related acute lung injury who were treated in The First Hospital of Zhangjiakou from August 2021 to June 2023,according to their prognosis,the patients were separated into a good prognosis group(87 cases)and a poor prognosis group(45 cases).General clinical data of the two groups were collected.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the levels of serum MUC1 and CD5L;χ^(2) test or t-test was applied to compare the general clinical data and serum levels;R language cor function was applied to analyze the correlation between the two serum indicators'levels and prognosis;multivariate Logistic regression was applied to analyze the influencing factors of prognosis,receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum MUC1 and CD5L levels for prognosis.Results:The disease severity,blood glucose,and MUC1 serum levels in the poor prognosis group were higher than those in the good prognosis group,while the CD5L serum level was lower in the poor prognosis group(all P<0.05).There was an obvious negative correlation between the levels of serum MUC1 and CD5L in patients,and between the levels of CD5L and prognosis,the correlation between MUC1 and prognosis was positive(all P<0.05).Logistic regression analysis showed that the CD5L serum level was a protective factor for poor prognosis in patients,while the APACHEⅡscore and MUC1 serum level were risk factors for poor prognosis of the patients(both P<0.05).ROC curve analysis showed that levels of serum MUC1 and CD5L could be used as predictive indicators for the prognosis of the patients with transfusion related acute lung injury,and the predictive value of their combined detection was higher(P<0.05).Conclusion:The levels of serum MUC1 and CD5L in patients with transfusion related acute lung injury are closely related to the prognosis,and the combination of the two has higher predictive value for the prognosis.