头孢曲松钠结合青霉素对妊娠晚期GBS感染患者凝血功能、母婴结局、血沉及C反应蛋白、PCT水平的影响

The Effect of Ceftriaxone Sodium Combined with Penicillin on Coagulation Function,Maternal and Infant Outcomes,Erythrocyte Sedimentation Rate,C-reactive Protein,and PCT Levels in Patients with GBS Infection in Late Pregnancy

探讨头孢曲松钠结合青霉素对妊娠晚期B族链球菌(GBS)感染患者凝血功能、母婴结局、血沉(ESR)及C反应蛋白(CRP)、降钙素原(PCT)水平的影响。选取2020年12月至2022年12月医院收治的妊娠晚期GBS感染患者106例,以随机数字表法分为研究组(n=53)、对照组(n=53)。对照组予以青霉素治疗,研究组在对照组基础上联合头孢曲松钠治疗。比较两组孕妇与新生儿不良结局、不良反应发生情况与凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、国际标准化比率(NR)、纤维蛋白原(FIB)]、ESR、CRP、PCT水平。研究组治疗后APTT、PT、INR水平分别为(28.62±4.05)s、(12.37±1.64)s、1.09±0.10,均高于对照组;FIB、ESR、CRP、PCT分别为(2.27±0.68)g/L、(18.92±2.15)mm/h、(12.73±2.26)mg/L、(0.64±0.12)ng/mL,均低于对照组(P<0.001);治疗后研究组孕妇不良结局、新生儿不良结局均为5.66%,均低于对照组的20.75%、18.87%(P<0.05);治疗期间两组不良反应发生率差异无统计学意义(P>0.05)。应用头孢曲松钠结合青霉素治疗妊娠晚期GBS感染患者可改善凝血功能与ESR、CRP、PCT水平,降低孕妇与新生儿不良结局,且具有较高的安全性。

To investigate the effects of ceftriaxone sodium combined with penicillin on coagulation function,maternal and infant outcomes,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),and procalcitonin(PCT)levels in patients with group B Streptococcus(GBS)infection in late pregnancy,a total of 106 patients with GBS infection in the third trimester of pregnancy from December 2020 to December 2022 were selected and randomly divided into study group(n=53)and control group(n=53)using a random number table method.The control group was treated with penicillin,while the study group was treated with ceftriaxone sodium in addition to the control group.The adverse outcomes,adverse reactions,and coagulation function indicators[activated partial thromboplastin time(APTT),prothrombin time(PT),international normalized ratio(INR),fibrinogen(FIB)],ESR,CRP,PCT levels,and ESR were compared between the two groups of pregnant women and newborns.The levels of APTT,PT,and INR in the study group after treatment were(28.62±4.05)s,(12.37±1.64)s,and 1.09±0.10,respectively,which were higher than those in the control group;and the levels of FIB,ESR,CRP,and PCT were(2.27±0.68)g/L,(18.92±2.15)mm/h,(12.73±2.26)mg/L,and(0.64±0.12)ng/mL,respectively,which were lower than those in the control group(P<0.001).After treatment,the adverse outcomes of pregnant women and newborns in the study group were 5.66%,which were lower than those in the control group(20.75%and 18.87%,respectively)(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).The application of ceftriaxone sodium combined with penicillin in the treatment of GBS infection in late pregnancy can improve coagulation function and the levels of ESR,CRP,and PCT,reduce adverse outcomes in pregnant women and newborns,and has high safety.