肝癌首次化疗患者生活质量与负性情绪的关系及影响因素

Influencing factors of quality of life in patients with liver cancer undergoing first chemotherapy and their relationship

目的:分析肝癌首次化疗患者生活质量的影响因素。方法:选择2021年6月-2023年6月收治的60例肝癌患者,收集患者年龄、性别等一般资料,并采用肝癌患者生活质量量表(QOL-LC)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、社会支持评定量表(SSRS)、家庭关怀度量表(APGAR)评估患者生活质量、负性情绪、社会支持水平及家庭关怀度,采用单因素分析及多因素Logistic回归分析肝癌患者生活质量的影响因素,采用pearson相关性分析肝癌患者生活质量与负性情绪、社会支持水平及家庭关怀度的关系。结果:60例患者QOL-LC得分范围为107~196分,平均158.93±15.89分。单因素分析显示,独居、卡氏功能评分、HAMA评分、HAMD评分、社会支持度及家庭关怀度均是肝癌患者生活质量的影响因素(t=2.032,2.876,61.499,63.672,79.097,82.342;P<0.05)。多因素Logistic回归分析显示,焦虑、抑郁、低水平社会支持是肝癌患者生活质量的独立危险因素(OR=3.888,3.418,0.291;95%置信区间为1.423~10.628,1.509~7.739,0.141~0.599)。pearson相关性分析显示,肝癌患者QOL-LC评分与HAMA评分、HAMD评分均呈负相关关系(r=-0.428,-0.475;P<0.001),与SSRS评分、APGAR评分呈正相关关系(r=0.524,0.537;P<0.001)。结论:心理状况、社会支持度均是肝癌首次化疗患者生活质量的独立影响因素。

Objective:To analyze the influencing factors of quality of life in patients with liver cancer undergoing first chemotherapy.Methods:A total of 60 patients with liver cancer admitted from June 2021 to June 2023 were selected.The general data such as age and gender of patients were collected.The quality of life,negative emotions,social support level and family care degree of patients were evaluated by Quality of Life Scale for Liver Cancer(QOL-LC),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Social Support Rating Scale(SSRS)and Family APGAR Index(APGAR).Univariate analysis and multivariate Logistic regression analysis were used to analyze the influencing factors of quality of life in patients with liver cancer.Pearson correlation analysis was applied to analyze the relationship of quality of life with negative emotions,social support level and family care degree in patients with liver cancer.Results:The QOL-LC score of 60 patients ranged from 107 to 196 points,with an average of(158.93±15.89)points.Univariate analysis showed that living alone,Karnofsky performance score,HAMA score,HAMD score,social support and family care degree were the influencing factors of quality of life in patients with liver cancer(t=2.032,2.876,61.499,63.672,79.097,82.342;P<0.05).Multivariate Logistic regression analysis revealed that anxiety,depression,low social support level were independent risk factors for quality of life in patients with liver cancer(O r=3.888,3.418,0.291;95%CI=1.423-10.628,1.509-7.739,0.141-0.599).Pearson correlation analysis manifested that QOL-LC score was negatively correlated with HAMA score and HAMD score(r=-0.428,-0.475;P<0.001),and was positively correlated with SSRS score and APGAR score(r=0.524,0.537;P<0.001).Conclusion:Psychological status,social support level are independent influencing factors of quality of life in patients with liver cancer undergoing first chemotherapy.