果糖摄入与肿瘤:我们知道些什么?

Fructose intake and tumors:what can we learn from them?

果糖是一种常见的单糖,目前主要以高果糖玉米糖浆的形式被大量使用。近年来,高果糖玉米糖浆的大量使用与肥胖、糖尿病、高脂血症等慢性代谢性疾病发病率升高相关,这也为肿瘤提供了有利于生长的代谢微环境。人群流行病学研究及动物实验发现果糖摄入与肿瘤的发生发展密切相关。本文旨在分析果糖在肿瘤细胞中的代谢途径及其特点,梳理果糖与肿瘤发展的实验证据,从而科学指导健康人群及肿瘤患者的饮食,同时也为肿瘤的预防和治疗提供参考。

Fructose,a common monosaccharide,is predominantly utilized in the form of high fructose corn syrup.The increasing prevalence of chronic metabolic disorders such as obesity,diabetes,and hyperlipidemia has been linked to the widespread consumption of high fructose corn syrup.Moreover,this dietary trend has been recognized to create a conducive metabolic milieu for tumor growth.While direct evidence establishing a causal relationship between fructose intake and tumorigenesis in humans remains sparse,a growing body of epidemiological and experimental research has identified a strong association between high fructose consumption and the initiation and progression of tumors.This study aims to enhance our comprehension of the metabolic pathways and properties of fructose in tumor cells,to elucidate experimental proof of the connection between fructose and tumor development,and to offer scientifically-backed dietary recommendations for both healthy individuals and cancer patients.By doing so,this investigation aims to serve as a valuable resource for the prevention and treatment of tumors.