医学定制膳食对转移性肺癌患者营养状况及生活质量的影响

Effect of medical custom diet on nutritional status and quality of life in patients with metastatic lung cancer

目的探索医学定制膳食(HDMTM)对转移性肺癌患者营养状况、疲劳感及生活质量的影响。方法前瞻性选取武汉市第三医院2021年6月至2023年6月期间收治的108例转移性肺癌患者,根据随机数字表法分为两组,对照组54例采用常规营养支持,干预组54例采用HDMTM支持,干预后,比较两组营养状况[血清白蛋白(ALB)、总蛋白(TP)、血红蛋白(Hb)]、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)]、癌因性疲乏评分、肺癌特异性生活质量评估表(FACT-L)评分。结果两组患者经干预14 d后,营养状态、肺功能均较治疗前有所改善,癌因性疲乏评分有所降低,FACT-L评分有所升高,差异均有统计学意义(P<0.05)。干预组干预后14 d的FEV1(92.84±4.52)%、MVV(91.29±5.45)L/min、FVC(3.55±0.39)L、Hb(111.12±6.57)g/L、ALB(43.11±4.58)g/L、TP(69.78±3.16)g/L优于对照组,差异有统计学意义(P<0.05),干预后14 d的情感疲乏(4.85±1.22)分、行为疲乏(3.13±1.52)分、躯体疲乏(3.38±1.19)分、认知疲乏评分(3.15±1.14)分均低于对照组,差异有统计学意义(P<0.05),干预后7 d FACT-L评分(82.85±5.25)分、干预后14 d FACT-L评分(93.35±4.25)分高于对照组,差异有统计学意义(P<0.05)。结论HDMTM更具有针对性、科学性,相比于常规营养治疗,在转移性肺癌患者中效果更为明显,不仅能够改善患者肺功能、营养状态,促进病情恢复,还能够缓解疲乏感,提高生活质量,利用价值更高。

Objective To explore the effects of medical customized diet(HDMTM)on nutritional status,fatigue and quality of life in patients with metastatic lung cancer.Method A prospective selection of 108 patients with metastatic lung cancer admitted to Wuhan Third Hospital between June 2021 and June 2023 was conducted.They were randomly divided into two groups using a random number table method.The control group(54 cases)received routine nutritional support,while the intervention group(54 cases)received HDMTM support.After intervention,the nutritional status of the two groups[serum albumin(ALB),total protein(TP),hemoglobin(Hb)],lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),maximum ventilation volume per minute(MVV)],cancer-related fatigue score,and lung cancer specific quality of life assessment(FACT-L)score)were compared.Result After 14 days of intervention,the nutritional status and lung function of the two groups of patients improved compared to before treatment.The cancer-related fatigue score decreased and the FACT-L score increased,with statistical significance(P<0.05).After 14 days of intervention,the improvement of FEV1(92.84±4.52)%,MVV(91.29±5.45)L/min,FVC(3.55±0.39)L,Hb(111.12±6.57)g/L,ALB(43.11±4.58)g/L,and TP(69.78±3.16)g/L in the intervention group was better than that in the control group,with statistical significance(P<0.05).The scores of emotional fatigue(4.85±1.22),behavioral fatigue(3.13±1.52),physical fatigue(3.38±1.19),and cognitive fatigue(3.15±1.14)after 14 days of intervention were lower than those of the control group,with statistical significance(P<0.05).The FACT-L score(82.85±5.25)and FACT-L score(93.35±4.25)after 7 days of intervention were higher than those of the control group,with statistical significance(P<0.05).Conclusion HDMTM is more targeted and scientific.Compared to conventional nutritional support,it has a more significant effect in patients with metastatic lung cancer.It can not only improve lung function and nutritional status,promote disease recovery,but also alleviate fatigue,improve quality of life,and have higher utilization value.