急性髓系白血病伴血小板计数减少的研究进展

Research progress in acute myeloid leukemia with thrombocytopenia

急性髓系白血病(AML)细胞与机体血小板之间的相互作用是导致血小板功能紊乱并加剧肿瘤进展的重要原因,这一病理过程主要通过AML细胞分泌细胞因子异常活化血小板、血小板表达膜糖蛋白掩护AML细胞逃逸、血小板分泌细胞因子下调免疫杀伤细胞实现。该文从AML伴血小板计数减少对机体的影响出发,重点叙述AML细胞与血小板之间相互作用的病理与分子机制,阐明血小板计数减少及相关参数恢复对机体的影响,并对基于血小板的靶向和模拟药物进行总结,旨在为临床工作者探索新的临床治疗靶点提供理论依据。

Acute myeloid leukemia(AML)cells and the platelets in platelet dysfunction is the interaction between the most important reason and tumor progression,the main pathological process by AML cells secreted cytokines abnormal expression of activated platelets,platelet membrane glycoproteins cover AML cells secrete cytokines and escape,platelet lowered immune killer cells.In this paper,from the AML with platelet count to reduce the influence of the body,described the AML cells and platelets pathology and molecular mechanism of interaction between,clarify the platelet count decreased and recovery of related parameters influence on the body,and to summarize drugs targeting based on platelets and simulation,aiming at clinical workers provides the theoretical foundation to explore new clinical therapeutic targets.