动态监测血清血清鳞状上皮细胞癌抗原细胞角蛋白19血清片段21-1人附睾蛋白4水平在非小细胞肺癌患者疗程中的变化及其临床价值

Dynamic monitoring of serum SCC-Ag,CYFRA21-1,and HE4 levels during treatment in non-small-cell lung carcinoma patients and its clinical value

目的动态监测血清鳞状上皮细胞癌抗原(SCC-Ag)、细胞角蛋白19血清片段21-1(CYFRA21-1)、人附睾蛋白4(HE4)水平在非小细胞肺癌患者疗程中的变化,并分析其临床应用价值。方法自2021年1月至2023年9月择取我院非小细胞肺癌患者108例为研究组,另收集同期良性肺病患者108例为作为对照组。分别检测良性肺病患者及非小细胞肺癌患者入院时血清SCC-Ag、CYFRA21-1、HE4水平;对比研究组不同治疗疗程患者血清各指标水平,并分析其诊断价值。结果入院时血清SCC-Ag、CYFRA21-1、HE4比较,研究组高于对照组(P<0.05);研究组患者血清SCC-Ag、CYFRA21-1、HE4水平:术后1 d>术后7 d>术后30 d>术后90 d;入院时血清SCC-Ag、CYFRA21-1、HE4水平联合诊断非小细胞肺癌的曲线下面积(AUC)为0.923,灵敏度为88.0%,特异度为83.3%。结论血清中SCC-Ag、CYFRA21-1、HE4表达水平在非小细胞肺癌患者中升高,并在不同术后疗程中存在降低,并发现三者联合检测可提高非小细胞肺癌的诊断效率,为肺癌的早期诊断及疗效评估提供新的手段。

Objective To dynamically monitor the serum levels of squamous cell carcinoma antigen(SCC-AG),cytokeratin 19 serum fragment 21-1(CYFRA21-1),and human epididymal protein 4(HE4)in patients with non-small-cell lung carcinoma and analyze its clinical application value.Methods From January of 2021 to September of 2023,108 non-small-cell lung carcinoma patients were selected as the study group and 108 benign pulmonary disease patients as the control group.The serum levels of SCC-Ag,CYFRA21-1,and HE4 were measured in patients with benign pulmonary disease at admission and in patients with non-small-cell lung carcinoma disease at admission,and compared with those in patients with different treatment courses in the study group.Results The serum levels of SCC-Ag,CYFRA21-1,and HE4 in the study group were significantly higher than those in the control group(P<0.05),and the serum levels of SCC-Ag,CYFRA21-1,and HE4 in the study group were 1 day after operation>7 days after operation>30 days after operation>90 days after operation.The area under the curve(AUC)of SCC-Ag,CYFRA21-1,and HE4 for the diagnosis of non-small-cell lung carcinoma was 0.923,and sensitivity and specificity were 88.0%and 83.3%.Conclusion The serum levels of SCC-Ag,CYFRA21-1,and HE4 were significantly increased in patients with non-small-cell lung carcinoma and significantly decreased in different postoperative periods,it was found that the combined detection of the three non-small-cell lung carcinoma could improve the diagnostic efficiency of lung cancer and provide a new method for early diagnosis and therapeutic evaluation of lung cancer.