血脂指标与血清转氨酶、胆碱酯酶、γ-谷氨酰转肽酶联合检验在非酒精性脂肪肝病诊断中的应用

Application of Blood Lipid Indicators and Serum Transaminases,Cholinesterase,γ-glutamyl Transpeptidase Combined Test in the Diagnosis of Non-alcoholic Fatty Liver Disease

目的:分析血脂指标联合血清转氨酶、胆碱酯酶(CHE)、γ-谷氨酰转移酶(GGT)诊断非酒精性脂肪肝病(NAFLD)的价值。方法:选择2022年1—12月中国贵航集团三0二医院收治的98例NAFLD患者纳入观察组,另将同期于本院体检的93例健康体检者纳入对照组。比较两组血脂指标[总胆固醇(TC)、甘油三酯(TG)]、转氨酶[谷草转氨酶(AST)、谷丙转氨酶(ALT)]、CHE、GGT的差异;另描绘受试者工作特征(ROC)曲线,分析TC、TG、AST、ALT、CHE、GGT单独或联合诊断NAFLD的价值。结果:观察组TC、TG、AST、ALT、CHE、GGT高于对照组,差异有统计学意义(P<0.05)。ROC曲线结果显示,TC、TG、AST、ALT、CHE、GGT联合诊断NAFLD的AUC高于单独诊断,差异有统计学意义(P<0.05)。结论:血脂指标联合血清转氨酶、CHE、GGT可有效诊断出NAFLD。

Objective:To analyze the application of blood lipid indicators and serum transaminases,cholinesterase(CHE),γ-glutamyl transpeptidase(GGT)combined test in the diagnosis of non-alcoholic fatty liver disease(NAFLD).Method:A total of 98 patients with NAFLD admitted to China Guihang Group 302 Hospital from January to December 2022 were included in the observation group,and 93 healthy subjects who underwent physical examination in our hospital during the same period were included in the control group.The differences of blood lipid indexes[total cholesterol(TC),triglyceride(TG)],aminotransferase[glutamic oxalic aminotransferase(AST),alanine aminotransferase(ALT)],CHE and GGT were compared between the two groups.Receiver operating characteristic(ROC)curve was also described to analyze the value of TC,TG,AST,ALT,CHE,GGT alone or in combination in the diagnosis of NAFLD.Result:TC,TG,AST,ALT,CHE and GGT in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).ROC curve results showed that the AUC of the combined diagnosis of TC,TG,AST,ALT,CHE and GGT were higher than those of the diagnosed alone,and the differences were statistically significant(P<0.05).Conclusion:Blood lipid indicators combined with serum transaminase,CHE,GGT can effectively diagnose NAFLD.